Table 1 Hemodynamic variables in instrumented awake sheep

PVRI (dyne/s/cm⁵/m²)

   rhAPC

194 ± 22

192 ± 22

179 ± 38

198 ± 58

202 ± 40

193 ± 38

195 ± 33

166 ± 20

   LPS

188 ± 12

810 ± 94*

359 ± 31*

252 ± 29

227 ± 21

266 ± 35

268 ± 54

248 ± 56

   LPS + rhAPC

201 ± 10

847 ± 124*

392 ± 44*

215 ± 29^†

224 ± 39^†

209 ± 41^†

229 ± 38^†

210 ± 41^†

PAOP (mmHg)

   rhAPC

8 ± 0

8 ± 0

9 ± 0

8 ± 1

10 ± 0

9 ± 1

9 ± 1

8 ± 1

   LPS

8 ± 0

18 ± 1*

12 ± 0*

12 ± 1*

12 ± 1*

12 ± 1*

13 ± 1*

11 ± 0*

   LPS + rhAPC

8 ± 1

15 ± 2*

12 ± 1*

11 ± 1*

10 ± 1*

11 ± 1*

11 ± 1*

10 ± 1

RAP (mmHg)

   rhAPC

3 ± 0

3 ± 1

6 ± 1*

5 ± 1*

5 ± 1

5 ± 1*

5 ± 0*

5 ± 1

   LPS

4 ± 1

5 ± 1

7 ± 1*

7 ± 2

7 ± 1*

7 ± 1*

8 ± 1*

8 ± 1*

   LPS + rhAPC

3 ± 1

2 ± 1

6 ± 1*

5 ± 1*

6 ± 1*

6 ± 1*

6 ± 2*

5 ± 2

Heart rate (beats/min)

   rhAPC

94 ± 8

91 ± 8

95 ± 6

92 ± 7

95 ± 4

97 ± 5

97 ± 6

92 ± 7

   LPS

106 ± 4

139 ± 14

129 ± 7

151 ± 9

134 ± 8

127 ± 7

142 ± 12

137 ± 11

   LPS + rhAPC

94 ± 5

158 ± 16*

112 ± 9*

151 ± 10* ^†

138 ± 11* ^†

128 ± 12*

122 ± 13

123 ± 12

MAP (mmHg)

   rhAPC

103 ± 3

100 ± 4

103 ± 3

106 ± 5

106 ± 2

101 ± 3

105 ± 1

100 ± 5

   LPS

101 ± 3

107 ± 5

110 ± 3*

90 ± 3* ^†

88 ± 4* ^†

93 ± 3^†

91 ± 3* ^†

90 ± 3* ^†

   LPS + rhAPC

101 ± 3

105 ± 4

108 ± 2

95 ± 4

95 ± 4

96 ± 5

95 ± 4

98 ± 5

SVRI (dyne/s/cm⁵/m²)

   rhAPC

1677 ± 70

1688 ± 82

1610 ± 108

1877 ± 327

1918 ± 302

1680 ± 204

1872 ± 186

1671 ± 268

   LPS

1587 ± 69

1976 ± 165*

1962 ± 90*

1212 ± 87* ^†

1089 ± 82* ^†

1278 ± 101* ^†

1267 ± 139* ^†

1194 ± 111* ^†

   LPS + rhAPC

1559 ± 68

1789 ± 153

1910 ± 107*

1302 ± 153^†

1226 ± 121^†

1268 ± 119^†

1337 ± 141^†

1367 ± 135^†

Cardiac index (l/min/m²)

   rhAPC

5.4 ± 0.6

5.3 ± 0.7

5.2 ± 0.4

5.0 ± 0.8

5.0 ± 0.7

5.2 ± 0.6

4.9 ± 0.6

5.1 ± 0.6

   LPS

5.3 ± 0.3

5.0 ± 0.7

4.3 ± 0.2*

6.0 ± 0.5^†

6.0 ± 0.2^†

5.7 ± 0.3^†

5.9 ± 0.5^†

6.0 ± 0.5^†

   LPS + rhAPC

5.1 ± 0.3

4.9 ± 0.4

4.3 ± 0.2

5.8 ± 0.3^†

6.1 ± 0.4^†

5.9 ± 0.4^†

5.7 ± 0.5^†

5.8 ± 0.5^†

SVI (ml/beat/m²)

   rhAPC

57 ± 3

57 ± 2

55 ± 2

54 ± 6

52 ± 7

55 ± 7

52 ± 8

57 ± 8

   LPS

49 ± 2

36 ± 2*

33 ± 2*

40 ± 4

46 ± 3

45 ± 2

44 ± 5

46 ± 4

   LPS + rhAPC

55 ± 2

33 ± 4*

40 ± 3*

39 ± 3*

46 ± 4*

49 ± 5

50^† ± 5

49 ± 5

LAP (mmHg)

   rhAPC

5 ± 1

5 ± 1

6 ± 2

6 ± 1

6 ± 1

6 ± 1

6 ± 1

7 ± 1

   LPS

5 ± 1

5 ± 1

8 ± 1*

8 ± 1*

8 ± 1*

9 ± 1*

9 ± 1*

9 ± 1*

   LPS + rhAPC

5 ± 1

3 ± 1

6 ± 1

9 ± 2*

8 ± 2*

9 ± 2*

8 ± 2*

9 ± 2*

LVSWI (g/m/m²)

   rhAPC

67 ± 3

69 ± 4

68 ± 3

69 ± 12

62 ± 8

63 ± 11

61 ± 12

64 ± 11

   LPS

62 ± 3

42 ± 3*

44 ± 2*

43 ± 4*

49 ± 5

50 ± 3*

47 ± 6*

49 ± 5*

   LPS + rhAPC

69 ± 4

42 ± 6*

52 ± 4*

44 ± 3*

53 ± 4*

56 ± 5*

56 ± 5*

59 ± 7

RVSWI (g/m/m²)

   rhAPC

11 ± 1

11 ± 1

9 ± 1

9 ± 1

9 ± 1

9 ± 1

9 ± 1

10 ± 2

   LPS

9 ± 0

22 ± 1*

9 ± 0

11 ± 1

12 ± 1

12 ± 1*

11 ± 1

10 ± 1

   LPS + rhAPC

10 ± 1

21 ± 2*

11 ± 1

9 ± 1

11 ± 1

10 ± 1

11 ± 2

11 ± 2