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Figure 3 | Critical Care

Figure 3

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

Figure 3

Only high-molecular-weight hyaluronan (1,600 kDa) significantly decreased the lung injury score. Animals were pretreated with either 1,600 kDa or 35 kDa hyaluronan 18 hours prior to ventilation. Lipopolysaccharide (LPS 1 mg/kg) was given by arterial injection 1 hour prior to the start of ventilation. After 4 hours of ventilation, animals were sacrificed and the left lung was fixed with formaldehyde, sliced and stained with hematoxylin and eosin. Lung injury, measured by the lung injury score as described in Materials and methods, showed substantial protection by 1,600 kDa hyaluronan but not 35 kDa hyaluronan. *P < 0.01 versus control, #P < 0.01 versus LPS. Non-vent, nonventilated.

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Critical Care

ISSN: 1364-8535