Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study

Table 6 Performance characteristics of urinary interleukin-18 (IL-18) to predict the development of sustained acute kidney injury

Variables	AUC-ROCC (95% CI)	P value
Increase in serum creatinine > 25% within 48 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.58 (0.46–0.71)	0.19
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.56 (0.43–0.69)	0.43
Increase in serum creatinine > 50% within 48 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.56 (0.38–0.74)	0.51
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.57 (0.40–0.73)	0.45
Increase in serum creatinine > 25% within 120 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.59 (0.47–0.71)	0.14
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.56 (0.43–0.68)	0.36
Increase in serum creatinine > 50% within 120 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.51 (0.34–0.67)	0.93
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.57 (0.42–0.73)	0.36
RIFLE R or worse (R: n = 31 + I: n = 13 + F: n = 6)
Urinary IL-18 on arrival in the intensive care unit	0.61 (0.48–0.74)	0.12
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.57 (0.43–0.71)	0.29
RIFLE I or worse (I: n = 13 + F: n = 6)
Urinary IL-18 on arrival in the intensive care unit	0.52 (0.37–0.67)	0.30
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.58 (0.43–0.73)	0.28

Acute kidney injury is defined as at least two consecutive significantly increased serum creatinine values. For RIFLE classes, serum creatinine increases within 120 hours postoperatively and urinary output during the first 24 hours postoperatively. AUC-ROCC, area under the curve for the receiver operating characteristic curve; CI, confidence interval; RIFLE, Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function, and End-stage kidney disease; RIFLE F, RIFLE Failure; RIFLE I, RIFLE Injury; RIFLE R, RIFLE Risk.

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