Figure 3

Cytokines are significantly altered in nonsurviving versus surviving patients who sustained inhalation injury. (a) IL-4 serum levels were significantly increased in the nonsurvivor group at admission compared with survivors (normal IL-4: 0 ± 0 pg/ml). (b) Nonsurvivors exhibited a significant increase in IL-6 serum levels 5 to 7 days after admission compared with the survivor group (normal IL-6: 8.7 ± 5 pg/ml). (c) Nonsurvivors exhibited a significant decrease in IL-7 serum levels 5 to 7 days after admission compared with the survivor group (normal IL-7: 3.8 ± 0.63 pg/ml). (d) IL-10 serum levels were significantly increased in the nonsurvivor group at admission and 5 to 7 days after admission compared with survivors (normal IL-10: 1.4 ± 0.3 pg/ml). (e) Nonsurvivors exhibited a significant increase in IL-13 serum levels upon hospital admission when compared with the survivor group (normal IL-13: 0.9 ± 0.2 pg/ml). Throughout the figure, histograms depict serum concentrations of the respective cytokine at steady state levels. Bars represent means; error bars correspond to standard error of the mean. *P < 0.05. pAD, post-admission days.