|  |  |  | Control group | ECMO group |  |
---|
Reference | Year | Study design | Patients total (n) |
n
| survival rate (%) |
n
| survival rate (%) |
P
|
[80] | 1985 | RCT 'play the winner'* | 12 | 1 | 0 | 11 | 100 | Not reported |
[82] | 1989 | RCT (phase 1+2) | 39 | 10 | 60 | 29 | 97 | <0.05 |
[81] | 1993 | RCT | 41 | 19 | 89 | 22 | 91 | NS |
[83] | 1996 | RCT | 185 | 92 | 41 | 93 | 68 | <0.001 |
[84] | 1999 | Uncontrolled study | 100 | - | - | 100 | 82 | - |
- *Bartlett et al [80] used a special randomized play-the-winner statistical method; the chance of randomly assigning an infant to one treatment or the other is influenced by the outcome of treatment of each patient in the study. If one treatment is more successful, more patients are randomly assigned to that treatment.