Figure 1From: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infectionModulation of receptor for advanced glycation end products (RAGE) protects mice from the effects of cecal ligation and puncture (CLP). Kaplan-Meier survival analysis following CLP comparing wild-type RAGE+/+ 129SvEvBrd mice (n = 15), RAGE-/- mice (n = 15), RAGE+/- mice (n = 23), and anti-RAGE monoclonal antibody-treated (15 mg/kg intravenously 30 to 60 minutes before CLP) wild-type mice (n = 15). P < 0.001 for each group in comparison with the wild-type CLP control group. Sham surgery-treated wild-type 129SvEvBrd mice (n = 5) were used as an additional control group. WT, wild-type.Back to article page