Study | Study type/patients or treatments included | Number of patients included | Study period | Reference |
---|---|---|---|---|
EVAA | Dose-finding phase II | 131 | 1997 to 1998 | [10] |
PROWESS | Phase III | 1,690 | 1998 to 2000 | [11] |
ENHANCE | Open-label | 2,378 | 2001 to 2003 | [12] |
ADDRESS | Low risk for death | 2,640 | 2002 to 2004 | [13] |
RESOLVE | Sepsis in children | 477 | 2002 to 2005 | [24] |
XPRESS | Heparin + DrotAA | 1,927 | 2003 to 2005 | [14] |