Table 6 Functional outcome data in patients with malignant middle cerebral artery infarction: studies with comparative data on conservative treatment versus decompressive surgery
From: Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke
Authors | Patients treated with conservative treatment | Patients treated with decompression | Mean age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
|---|---|---|---|---|---|---|---|---|---|---|---|
Delashaw et al., 1990 [118] | 4 | Â | NA | 100%/0% | NA | NA | NA | 0% | 0% | 0% | 100% |
| Â | Â | 9 | 57 | 0%/100% | 56% | NA | 15 | 22% | 22% | 44% | 11% |
Steiger 1991 [119] | 7 | Â | NA | NA | NA | NA | 6 | 0% | 0% | 0% | 100% |
| Â | Â | 8 | NA | NA | NA | NA | 6 | 75% | 75% | 75% | 25% |
Rieke et al., 1995 [77] | 55 | Â | 56 | 62%/38% | 22% | NA | 1 | 22% | 22% | 22% | 78% |
Hacke et al., 1996 [3] | Â | 63 | 50 | 17%/83% | 35% | 30 | 3 | 2% | 40% | 33% | 25% |
Wirtz et al., 1997 [104] | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Schwab et al., 1998 [109] | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Mori et al., 2001 [120] | 21 | Â | 72 | 52%/48% | 33% | NA | 6 | 5% | 0% | 24% | 71% |
Mori et al., 2004 [111] | Â | 50 | 65 | 26%/74% | 36% | 63 | 6 | 10% | 10% | 56% | 24% |
Kuroki et al., 2001 [121] | 7 | Â | 80 | NA | NA | NA | NA | 14% | 14% | 14% | 86% |
| Â | Â | 8 | 72 | NA | NA | NA | NA | 87% | 87% | 87% | 13% |
Holtkamp et al., 2001 [114] | 12 | Â | 73 | 83%/17% | 67% | NA | 9 | 0% | 0% | 17% | 83% |
| Â | Â | 12 | 65 | 25%/75% | 42% | 42 | 5 | 0% | 0% | 67% | 33% |
Cho et al., 2003 [115] | 10 | Â | 64 | 60%/40% | 50% | NA | 6 | 20% | 20% | 20% | 80% |
| Â | Â | 42 | 63 | 52%/48% | 38% | 50 | 6 | 71% | 71% | 71% | 29% |
Maramattom et al., 2004 [116] | 10 | Â | 63 | 40%/60% | 0% | NA | 1 | 0% | 10% | 30% | 60% |
| Â | Â | 14 | 55 | 22%/78% | 71% | 36 | 1 | 0% | 38% | 63% | 0% |
Yang et al., 2005 [122] | 14 | Â | 66 | 43%/57% | 57% | NA | 3 | 0% | 0% | 36% | 64% |
| Â | Â | 10 | 59 | 30%/70% | 60% | 62 | 3 | 10% | 30% | 50% | 10% |
Wang et al., 2006 [117] | 41 | Â | 67 | 56%/44% | NA | NA | 6 | 0% | 25% | 54% | 22% |
| Â | Â | 21 | 62 | 38%/62% | NA | 48 | 6 | 0% | 14% | 57% | 29% |
Authors | Patients treated with hypothermia | Patients treated with decompression | Mean age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
Georgiadis et al., 2002 [124] | 19 | Â | 56 | 100%/0% | 26% | NA | NA | NA | NA | NA | 47% |
| Â | Â | 17 | 52 | 0%/100% | 24% | 30 | NA | NA | NA | NA | 12% |
Authors | Patients treated with decompression + hypothermia | Patients treated with decompression | Mean Age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
Els et al., 2006 [125] | 12 | Â | 49 | NA | NA | 15 | 6 | 92% (median mRS 2) | Â | Â | 8% |
| Â | Â | 13 | 49 | NA | NA | 15 | 6 | 88% (median mRS 3) | Â | Â | 12% |