Table 1 Hemodynamic and gas exchange parameters in anesthetized dogs after isotonic saline infusion with or without carboxy-PTIO
From: Beneficial effect of carboxy-PTIO on hemodynamic and blood gas changes in septic shock dogs
| Â | Â | Â | Â | Â | Hours | Â | Â |
|---|---|---|---|---|---|---|---|
Parameters | Treatment | 0 | 0.5 | 1 | 2 | 3 | 4 |
HR (beats/min) | Saline | 145 ± 18 | 135 ± 18 | 128 ± 23 | 133 ± 18 | 143 ± 13 | 152 ± 15 |
|  | Carboxy-PTIO | 152 ± 14 | 153 ± 14 | 150 ± 11 | 157 ± 11 | 151 ± 8 | 155 ± 9 |
MPAP (mmHg) | Saline | 15 ± 2 | 15 ± 2 | 15 ± 2 | 15 ± 2 | 16 ± 1 | 16 ± 0 |
|  | Carboxy-PTIO | 16 ± 2 | 16 ± 1 | 15 ± 1 | 15 ± 1 | 16 ± 2 | 17 ± 2 |
PCWP (mmHg) | Saline | 7 ± 2 | 7 ± 2 | 6 ± 2 | 8 ± 3 | 7 ± 3 | 5 ± 1 |
|  | Carboxy-PTIO | 7 ± 1 | 7 ± 1 | 7 ± 1 | 8 ± 1 | 8 ± 1 | 8 ± 1 |
CVP (mmHg) | Saline | 4± 1 | 5 ± 0 | 5 ± 1 | 4 ± 1 | 4 ± 1 | 5 ± 0 |
|  | Carboxy-PTIO | 5 ± 1 | 5 ± 1 | 5 ± 1 | 5 ± 1 | 5 ± 1 | 5 ± 1 |
PVRI (dyn s/cm5m2) | Saline | 168 ± 5 | - | 176 ± 32 | 186 ± 27 | 214 ± 51 | 225 ± 57 |
|  | Carboxy-PTIO | 163 ± 10 | - | 164 ± 21 | 168 ± 17 | 175 ± 31 | 199 ± 31 |
DO2I (ml min/m2) | Saline | 701 ± 91 | - | 636 ± 122 | 608 ± 108 | 633 ± 103 | 632 ± 85 |
|  | Carboxy-PTIO | 705 ± 97 | - | 647 ± 78 | 535 ± 26 | 553 ± 12 | 575 ± 30 |
VO2I (ml min/m2) | Saline | 112 ± 7 | - | 116 ± 6 | 118 ± 11 | 121 ± 10 | 123 ± 9 |
|  | Carboxy-PTIO | 103 ± 8 | - | 114 ± 14 | 120 ± 3 | 132 ± 7 | 137 ± 8 |