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Table 3 Phase II protocol: cytokine and neutrophil proteases

From: Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability

 

Serum baseline

Serum 180 min

BAL fluid

High Vt low PEEP group

   IL-1

0.0 ± 0.0

145.3 ± 72.7

1407.1 ± 338.7

   IL-6

126.4 ± 15.5

969.1 ± 321.8

589 ± 146.6

   IL-8

10.2 ± 5.9

7.6 ± 3.0

18.0 ± 4.3

   IL-10

0.0 ± 0.0

1.3 ± 0.8

2.4 ± 0.9

   TNF-α

47.7 ± 29.2

2.8 ± 2.0

9.9 ± 2.4

   MMP-2

730.3 ± 41.2

686.0 ± 25.8

705.5 ± 115.5

   MMP-9

571.7 ± 91.0

768.2 ± 123.8

1056.8 ± 126.8

   NE

91.7 ± 3.9

52.1 ± 7.5*

52.7 ± 14.4

Low Vt high PEEP group

   IL-1

0.0 ± 0.0

157.4 ± 103.8

739.3 ± 60.0

   IL-6

63.3 ± 19.9

1736.7 ± 1106.0

662.9 ± 162.6

   IL-8

11.8 ± 4.5

14.8 ± 9.0

35.2 ± 11.0

   IL-10

0.0 ± 0.0

3.5 ± 2.5

1.9 ± 0.8

   TNF-α

195.6 ± 86.7

27.9 ± 18.6

9.7 ± 3.3

   MMP-2

877.0 ± 41.9

778.0 ± 103.6

557.3 ± 86.5

   MMP-9

627.7 ± 264.7

1315.0 ± 403.9

1240.3 ± 186.0

   NE

37.0 ± 1.6†

8.9 ± 4.6*†

27.3 ± 7.5

  1. Shown are cytokine and neutrophil proteases in serum and bronchoalveolar lavage (BAL) fluid. Intereukin (IL)-1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α values are expressed as concentration in pg/ml. Concentrations of matrix metalloproteinase (MMP)-2 and MMP-9 are expressed in densitometric units (DU), and neutrophil elastase (NE) as nanomoles of elastase substrate degraded per milligram of protein per 18 hours and expressed as the degradation of substrate over time (nmol/l per 18 hours per mg). Data are expressed as mean ± standard error.*P < 0.05 versus baseline;†P < 0.05 versus high Vt/low PEEP for same time point. Vt, tidal volume; PEEP, positive end-expiratory pressure.
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Critical Care

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