HES 130/0.4, a new HES specification: tissue storage after multiple infusions in rats

Table Radioactivity per organ expressed as percentage of the administered total HES dosage (mean)

	Days after the last administration
	3		10		24		52
Organ	HES 130	HES 200	HES 130	HES 200	HES 130	HES 200	HES 130	HES 200
n	8	8	8	8	4	4	4	4
Total	4.32^*	7.72	2.04^*	3.97	1.38^*	2.86	0.65^*	2.45
Carcass	3.03^*	6.02	1.56^*	3.29	1.09^*	2.33	0.49^*	2.03
Liver	1.09^*	1.44	0.37^*	0.56	0.24^*	0.45	0.05	0.26
Spleen	0.07	0.12	0.05	0.06	0.03	0.04	0.03	0.06
Kidney	0.11	0.13	0.05	0.05	0.02	0.02	0.02	0.02
Lymph node	0.02	0.01	0.01	0.01	0.00	0.03	0.06	0.08

ISSN: 1364-8535