Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure

Table 3 Overview of published data on the effect of MARS™ and Prometheus™ on serum cytokines

Device	Reference	Patients n/Diagnosis	IL-6 Method/Effect	IL-8 Method/Effect	IL-10 Method/Effect	TNF Method/Effect	sTNF-αR1+2 Method/Effect
MARS	Guo et al. [22]	11/ALF 13/ACLF	FACS/Decrease	ELISA/Decrease	FACS/No change	FACS/Decrease	Not available
MARS	Ambrosino et al. [20]	17/ACLF	Not provided/Increase	Not available	Not available	Not provided/Decrease	Not available
MARS	Sen et al. [19]	18/ACLF	ELISA/No change	ELISA/No change	ELISA/No change	ELISA/No change	ELISA/No change
MARS	Auth et al. [21]	2/ALF	ELISA/Decrease in albumin circuit	Not available	Not available	ELISA/Decrease in albumin circuit	Not available
MARS	Isoniemi et al. [33]	49/ALF	ELISA/No change	ELISA/No change	ELISA/Decrease	ELISA/No change	Not available
MARS	Di Campli et al. [23]	10/ALF	ELISA/Decrease	Not available	Not available	ELISA/Decrease	Not available
Prometheus	Rifai et al. [9]	7/ACLF 2/Graft dysfunction	ELISA/No change	Not available	Not available	ELISA/No change	Not available

Only full papers published in English are included. ACLF, acute-on-chronic liver failure; ALF, acute liver failure; ELISA, enzyme-linked immunosorbent assay; FACS, fluorescence-activated cell sorting; IL, interleukin; MARS, molecular adsorbent recirculating system; TNF, tumor necrosis factor; TNF-R, tumor necrosis factor-receptor.

ISSN: 1364-8535