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Figure 2 | Critical Care

Figure 2

From: Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis

Figure 2

Landmark logistic and Cox regression analysis of DrotAA treatment effect by time to treatment. With the use of logistic (odds ratios for DrotAA versus placebo) and Cox (hazard ratios for DrotAA versus placebo) regression analyses, modeling of the treatment effect as a function of time to treatment was performed. In both analyses there was a trend (logistic regression, p = 0.06; Cox regression, p = 0.07) toward a more beneficial effect with earlier administration of DrotAA (solid line, ratios less than 1 until 36 hours). The most precise estimates of the model were between 12 and 24 hours, as indicated by the narrowest 95% confidence intervals (dashed lines). Outside this range, estimates of benefit were much less precise (that is, wider 95% confidence intervals furthest from the solid line). DrotAA, drotrecogin alfa (activated).

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Critical Care

ISSN: 1364-8535