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Table 4 Clinical features of patients according to cause of acute tubular necrosis

From: Patients with ischaemic, mixed and nephrotoxic acute tubular necrosis in the intensive care unit – a homogeneous population?

Clinical feature

Cause of acute tubular necrosis

 

Ischaemic (n = 265)

Mixed (n = 201)

Nephrotoxic (n = 58)

Multiorgan failure

122 (46%)

110 (55%)

4 (7%)

Respiratory failure

230 (87%)

193 (96%)‡*

40 (69%)

Shock

220 (83%)

175 (87%)

8 (14%)

Hepatic failure

37 (14%)

16 (8%)

2 (3%)

Coma

106 (40%)

68 (34%)

12 (21%)

Infection

143 (54%)

149 (74%)‡*

31 (53%)

Gastrointestinal bleeding

45 (17%)

24 (12%)

4 (7%)

Oliguria

130 (49%)

116 (58%)

22 (38%)

Hypervolaemia

37 (14%)

40 (20%)

6 (10%)

Acidosis

193 (73%)

163 (81%)

37 (64%)

Admission creatinine (mg/dl)

1.98 ± 0.88

1.81 ± 0.88

1.63 ± 0.85

Peak creatinine (mg/dl)

3.24 ± 1.59

3.41 ± 1.50

2.78 ± 1.03

Discharge creatinine (mg/dl)

2.70 ± 1.47

2.98 ± 1.56*

1.96 ± 0.96

Dialysis

24 (9%)

34 (17%)*

4 (7%)

Mortality

175 (66%)

127 (63%)

22 (38%)

  1. Data are expressed as mean ± standard deviation or as n (%). *P < 0.017 ischaemic versus mixed acute tubular necrosis ATN; P < 0.017 ischaemic versus nephrotoxic ATN; P < 0.017 mixed versus nephrotoxic ATN.