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Table 4 Standard and modified thromboelastography with and without fresh frozen plasma administration (pooled data)

From: Molecular adsorbent recirculating system and hemostasis in patients at high risk of bleeding: an observational study

 

TP1

TP2

TP3

p

Patients with FFP administration

    

   Reaction time (mm)

19.4 (13.8–25.6)

20 (15.9–23.9)

17.4 (15.1–23)

0.46

   Coagulation time (mm)

16 (9.1–37.8)

25.5 (10.2–45.7)

25.1 (13–33.9)

0.02

   Maximal amplitude (mm)

34.2 (23.2–42.2)

29 (22.5–43)

29.7 (20.5–40.5)

0.015

   Angle alpha (degree)

30.2 (17–51.2)

34.2 (18.5–45.7)

21 (17.5–37)

0.06

   Clot lysis

100 (100-100)

100 (100-100)

100 (100-100)

0.84

   Coagulation index (percent)

-2.2 (-14.4–2.5)

-5 (-11.5–1.9)

-4.7 (-8.6–1.1)

0.9

   RHEP (mm)

1 (-0.7–2.2)

3 (-0.1–6.8)

0.7 (-0.6–4.1)

0.64

   MAPLT (mm)

20 (12–30.3)

21.5 (15–31)

24 (13.8–32.2)

0.22

Patients without FFP administration

    

   Reaction time (mm)

15.9 (13–19.4)

16.8 (13–19.3)

16.4 (10.9–20.5)

0.71

   Coagulation time (mm)

11.3 (7–19.7)

9.4 (6.3–21)

14.2 (5–32)

0.6

   Maximal amplitude (mm)

40 (32–52)

37.5 (28.3–52.6)

36.5 (24.8–53.3)

0.006

   Angle alpha (degree)

35.5 (28.5–51)

47.5 (30–57)

35.5 (21.2–57.7)

0.028

   Clot lysis (percent)

100 (98.6–100)

100 (98.6–100)

100 (97.8–100)

0.77

   Coagulation index

0.38 (-3.4–4.2)

-0.1 (-2.3–3.8)

0.3 (-7.7–4.8)

0.73

   RHEP (mm)

0.7 (-0.4–2.8)

2.9 (0.3–4.7)

1.9 (0.7–4)

0.03

   MAPLT (mm)

24.4 (12.5–31.2)

20 (8.5–27.5)

13.5 (6.2–27.5)

0.95

  1. MAPLT, difference between standard and abximimab-fab-modified maximal amplitude (MA) reflecting solely the platelet function. RHEP, difference between standard and heparinase modified reaction time (R) reflecting the effects of endo/exogenous heparinoids on plasmatic coagulation. FFP, fresh frozen plasma; TP, time point