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Table 1 Responses to acute and/or chronic hypoxia in which hypoxia inducible factor-1 is involved

From: Lactate as a marker of energy failure in critically ill patients: hypothesis

Pathway involved

Gene controlled

References of interest

Glycolysis

Aldolase A–C

[46,47]

 

Enolase 1

 
 

Glucose transporter 1–3

 
 

Glyceraldehyde phosphate dehydrogenase

 
 

Hexokinase 1–2

 
 

Lactate dehydrogenase A

 
 

Phosphofructokinase L

 
 

Pyruvate kinase 1-M

 

Erythropoiesis

Erythropoietin

[48]

Angiogenesis

Vascular endothelial growth factor

[49]

Vascular tone

Endothelin-1

[50-52]

 

Hemeoxygenase-1

 
 

Nitric oxide synthase 2

 
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Critical Care

ISSN: 1364-8535