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Table 1 Concentrations of protein C, APC, or rhAPC in humans

From: New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)

 

Concentrations (ng/ml)

Normal endogenous protein C levels

4,000

Normal endogenous APC levels

1

rhAPC in PROWESS patients (median steady-state levels)

45

Levels of APC/rhAPC used in many non-clinical in vitro/in vivo studies

1,000–20,000

  1. APC, activated protein C; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; rhAPC, recombinant human activated protein C (drotrecogin alfa [activated]).
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Critical Care

ISSN: 1364-8535