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Table 5 Multiple logistic regression model of patient factors in relation to ultimate hospital mortality

From: Case mix and outcomes for admissions to UK adult, general critical care units with chronic obstructive pulmonary disease: a secondary analysis of the ICNARC Case Mix Programme Database

 

Deaths

n

(%)

Unadjusted OR (95% CI)

Adjusted OR (95% CI)

Age

   

1.59 (1.46 – 1.73)

1.57 (1.44 – 1.73)

   <55

103

469

(22.0)

per 10 year increase

per 10 year increase

   55 – 60

108

395

(27.3)

  

   60 – 64

187

556

(33.6)

  

   65 – 69

281

745

(37.7)

  

   70 – 74

325

747

(43.5)

  

   75 – 79

293

537

(54.6)

  

   80+

96

162

(59.3)

  

Sex

     

   Female

630

1742

(36.2)

Ref.

Ref

   Male

763

1869

(40.8)

1.19 (1.03 – 1.39)

1.04 (0.88 – 1.22)

Severe respiratory disease

     

   No

827

2204

(37.5)

Ref.

Ref.

   Yes

487

1200

(40.6)

1.15 (0.98 – 1.34)

1.23 (1.03 – 1.46)

Home ventilation

     

   No

1288

3337

(38.6)

Ref.

Ref.

   Yes

26

67

(38.8)

1.05 (0.62 – 1.78)

1.16 (0.65 – 2.07)

Steroid treatment in previous 6 months

     

   No

1204

3110

(38.7)

Ref.

Ref.

   Yes

110

294

(37.4)

0.96 (0.74 – 1.24)

1.00 (0.75 – 1.33)

Comorbidity: liver disease

     

   No

1309

3398

(38.5)

Ref.

Ref.

   Yes

5

6

(83.3)

8.22 (0.96 – 70.47)

3.70 (0.39 – 35.37)

Comorbidity: cardiovascular disease

     

   No

1282

3326

(38.5)

Ref.

Ref.

   Yes

32

78

(41.0)

1.03 (0.63 – 1.68)

0.88 (0.51 – 1.50)

Comorbidity: chronic renal failure

     

   No

1306

3393

(38.5)

Ref.

Ref.

   Yes

8

11

(72.7)

3.29 (0.82 – 13.17)

2.21 (0.50 – 9.77)

Comorbidity: immunosuppression

     

   No

1299

3377

(38.5)

Ref.

Ref.

   Yes

15

27

(55.6)

1.92 (0.89 – 4.17)

1.75 (0.71 – 4.28)

Comorbidity: metastatic cancer

     

   No

1310

3398

(38.6)

Ref.

Ref.

   Yes

4

6

(66.7)

3.28 (0.60 – 17.96)

2.50 (0.43 – 14.66)

Length of stay before unit admission (days)

   

1.02 (1.01 – 1.03)

1.02 (1.01 – 1.03)

   0

567

1618

(35.0)

per 1 day increase

per 1 day increase

   1

256

753

(34.0)

  

   2

111

282

(39.4)

  

   3+

449

927

(48.4)

  

CPR within 24 hours before admission

     

   No

1207

3291

(36.7)

Ref.

Ref.

   Yes

176

301

(58.5)

2.38 (1.83 – 3.08)

1.83 (1.37 – 2.45)

Intubation statusa

     

   Not intubated

206

684

(30.1)

Ref.

Ref.

   Definitely/probably intubated

1187

2927

(40.6)

1.71 (1.38 – 2.13)

1.36 (1.07 – 1.73)

Lowest pHa

   

1.31 (1.23 – 1.40)

1.23 (1.13 – 1.35)

   <7.18

391

758

(51.6)

per 0.1 decrease

per 0.1 decrease

   7.18–7.25

294

797

(36.9)

  

   7.26–7.32

259

815

(31.8)

  

   = 7.33

297

877

(33.9)

  

PaCO2 from ABG with lowest pH (kPa)a

   

1.09 (0.91 – 1.29)

1.01 (0.79 – 1.29)

   <6.9

334

784

(42.6)

per 10 kPa increase

per 10 kPa increase

   6.9–8.6

316

836

(37.8)

  

   8.7–10.6

270

783

(34.5)

  

   = 10.7

320

843

(38.0)

  

PaO2/FiO2 gradient (kPa)a

   

1.17 (1.09 – 1.26)

1.13 (1.04 – 1.22)

   <17.2

425

871

(48.8)

per 10 kPa decrease

per 10 kPa decrease

   17.2–22.8

300

860

(34.9)

  

   22.9–29.5

293

856

(34.2)

  

   = 29.6

294

852

(34.5)

  

Lowest albumin (g/l)a

     

   <20

178

303

(58.8)

2.73 (2.11 – 3.54)

1.94 (1.46 – 2.58)

   20–24

208

477

(43.6)

1.49 (1.20 – 1.84)

1.28 (1.01 – 1.61)

   = 25 or not recorded

1007

2831

(35.6)

Ref.

Ref.

Organ system failure: respiratory

     

   No

335

786

(42.6)

Ref.

Ref.

   Yes

1058

2825

(37.5)

1.09 (0.87 – 1.36)

0.71 (0.55 – 0.91)

Organ system failure: cardiovascular

     

   No

881

2594

(34.0)

Ref.

Ref.

   Yes

512

1017

(50.3)

2.21 (1.87 – 2.62)

1.48 (1.22 – 1.79)

Organ system failure: neurological

     

   No

1066

2978

(35.8)

Ref.

Ref.

   Yes

327

633

(51.7)

1.85 (1.53 – 2.24)

1.36 (1.10 – 1.68)

Organ system failure: renal

     

   No

1190

3346

(35.6)

Ref.

Ref.

   Yes

203

265

(76.6)

5.17 (3.70 – 7.23)

3.83 (2.67 – 5.47)

Organ system failure: haematological

     

   No

1362

3550

(38.4)

Ref.

Ref.

   Yes

31

61

(50.8)

1.65 (0.94 – 2.89)

1.30 (0.69 – 2.45)

  1. Ultimate hospital mortality excludes admissions who were readmissions to the intesnive care unit within the same hospital stay, admissions whose ultimate hospital discharge status was missing, and admissions for whom any of the entered risk factors were missing. aDuring first 24 hours following unit admission. ABG, arterial blood gas; CI, confidence interval; CPR, cardiopulmonary resuscitation; FiO2, fractional inspired oxygen; OR, odds ratio; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension.
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