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Table 6 Recovery results for patients who became eligible to start the extubation process within 5 days of the start of the study drug infusion

From: Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Parameter

Remifentanil (n = 47)

Fentanyl (n = 22)

Morphine (n = 28)

Median time on mechanical ventilation during the treatment period, h (range)

24.83 (12.5–110.2)

24.08 (16.4–70.0)

37.04 (17.8–98.2)

   Hazard ratio relative to comparator

 

1.21

0.71

   95% CI

 

0.70, 2.10

0.43, 1.18

   P

 

0.500

0.188

Median time from the start of the extubation process until actual extubation, h (range)

1.00 (0.0–97.2)

0.68 (0.0–5.6)

1.93 (0.0–96.2)

   Hazard ratio relative to comparator

 

1.23

0.42

   95% CI

 

0.70, 2.13

0.25, 0.71

   P

 

0.474

0.001

Median time from the start of extubation process until ICU discharge, h (range)

43.50 (2.4–150.0)

42.90 (2.2–120.6)

49.63 (3.7–144.2)

   Hazard ratio relative to comparator

 

1.34

0.98

   95% CI

 

0.76, 2.37

0.56, 1.70

   P

 

0.316

0.928

  1. CI, confidence interval; ICU, intensive care unit.