Figure 4
From: Bench-to-bedside review: Toll-like receptors and their role in septic shock
The intracellular signaling pathways of the Toll-like receptor 2 (TLR2) complex. Akt, intracellular protein kinase; IKB, inhibitory subunit κB; IKK, I-κB kinase; IRAK, IL-1 receptor-associated kinase; MyD88, myeloid differentiation factor; NF-κB, nuclear factor-κB; NIK, nuclear factor-κB inducing kinase; PG, peptidoglycan; PI3K, phosphatidyl inositol-3'-kinase; Rac, Rho-type GTPase; TIR, Toll IL-1 receptor; Tollip, Toll interactive protein; TRAF6, tumor necrosis factor receptor-associated factor 6.