Table 1 Characteristics of all 87 included patients
From: Relationship between acid–base status and inflammation in the critically ill
Demographic features | Value |
|---|---|
Age, years | 52 (35 to 60) |
Male, number of patients (%) | 46 (53%) |
Simplified acute physiology score 3 | 52 (41 to 67) |
Sequential organ failure assessment score at admission | 5 (2 to 9) |
Laboratory data at admission | |
Hemoglobin, g/dL | 11 (2.32) |
Hematocrit (%) | 33.4 (6.8) |
Leucocytes, cells/mm3 | 11,070 (7,400 to 16,000) |
Platelets, units/mm3 | 174 (130 to 260) |
Na, mEq/L | 140 (9.2) |
K, mEq/L | 4.1 (0.9) |
Cl, mEq/L | 106 (9.4) |
P, mg/dL | 2.24 (0.99) |
Creatinine, mg/dL | 1.24 (0.8 to 2.8) |
pH | 7.39 (7.33 to 7.41) |
pCO2, mmHg | 38.72 (10.8) |
HCO3 -, mEq/L | 21.83 (5.0) |
SBE, mEq/L | -2.9 (5.5) |
SIG, mEq/L | 8.92 (5.13) |
SIDa, mEq/L | 40.7 (4.89) |
Lactate, mEq/L | 1.55 (1.11 to 2.22) |
Albumin, g/dL | 2.91 (0.73) |
Specific reasons for admission, number of patients (%) | |
Sepsis | 27 (31%) |
Surgery | 3 (3%) |
Organ dysfunction and need for support, number of patients (%) | |
Shock | 25 (28%) |
Norepinephrine dose <0.3 mcg/kg/min | 8 (9%) |
Norepinephrine dose ≥0.3 mcg/kg/min | 18 (20%) |
Steroid use for shock | 18 (20%) |
Use of mechanical ventilation | 19 (22%) |
PO2/FiO2 ratio <100 | 1 (1%) |
Acute kidney injury | 27 (31%) |
Need for renal replacement therapy | 25 (29%) |
Continuous method | 14 (16%) |
Outcomes, number of patients (%) | |
ICU mortality | 20 (23%) |
Hospital mortality | 26 (30%) |
Cytokine levels, pg/mL | |
IL1β | 2.1 (1.2 to 4.1) |
IL1RA | 25.4 (12 to 59.7) |
IL2 | 7.5 (4.9 to 12.8) |
IL4 | 7.18 (2.41 to 18.76) |
IL6 | 45.76 (11.2 to 110) |
IL7 | 13.3 (7.0 to 20.9) |
IL8 | 36.3 (19.3 to 81.8) |
IL9 | 2.0 (0.2 to 3.7) |
IL10 | 17.7 (7.4 to 57.9) |
IL17 | 3.5 (1.8 to 8.1) |
TNFα | 25.7 (12.5 to 45.0) |
IFNα | 66.3 (52.5 to 93.2) |
IFNγ | 9.4 (5.4 to 16.8) |
VEGF | 161 (104 to 311) |
CXCL1 | 1275 (901 to 2,338) |
MCP1 | 401 (226.5 to 1,450.0) |