From: Early adaptive immune suppression in children with septic shock: a prospective observational study
Characteristic | All | Persistent or nosocomial infection, | No persistent or nosocomial infection | P a |
---|---|---|---|---|
 | (n = 22) | (n = 6) | (n = 16) |  |
Age, years | 1.3 [0.3–14] | 8 [0.9 – 16] | 0.9 [0.2–12] | 0.1 |
Female gender, n (%) | 10 (45) | 2 (33) | 8 (50) | 0.6 |
Complex chronic condition, n (%) | 8 (36) | 3 (50) | 5 (31) | 1 |
Initial OFI ≥ 3, n (%)b | 10 (45) | 5 (83) | 5 (31) | 0.06 |
Initial PRISM IIIb | 11.5 [9 – 14] | 10.5 [8.8 – 12.5] | 13 [8 – 16] | 0.4 |
Initial PELODb | 12 [11 – 18] | 12 [1 – 14] | 12 [11 – 21] | 0.3 |
Site of initial infection, n (%) | Â | Â | Â | Â |
  Culture negative | 4 (18) | 0 | 4 (25) |  |
  Blood | 4 (18) | 2 (33) | 2 (13) |  |
  Lung | 8 (36) | 3 (50) | 5 (31) |  |
  Urine | 2 (9) | 0 | 2 (13) |  |
  Abdomen | 1 (5) | 0 | 1 (6) |  |
  Multisite | 3 (14) | 1 (17) | 2 (13) |  |
Glucocorticoid use, n (%)c | Â | Â | Â | Â |
  MP/Dex for < 24 hoursd | 8 (36) | 1 (17) | 7 (44) | 0.4 |
  MP/Dex for > 24 hours | 4 (18) | 3 (50) | 1 (6) | 0.046 |
  HCTZ for > 24 hoursd | 4 (18) | 0 | 4 (25) | 0.5 |
Outcomes | Â | Â | Â | Â |
  ICU-free days in 28 days | 17 [10 – 21] | 5.5 [0–16] | 19.2 [15 – 22] | 0.05 |
  Mortality, n (%) | 2 (9) | 1 (17) | 1 (6) | 0.4 |