Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients

Table 1 Summary of results of serial measurements of both plasma and urinary NGAL to predict AKI at different time points

	Number of patients	Threshold values (ng/mL)	Sensitivity (95% CI)	Specificity (95% CI)	NPV	AUROC
pNGAL at 0h for AKI occurrence at 24, 48 or 72 h	187	400	0.6 (0.43-0.74)	0.85 (0.77-0.91)	0.86	0.7668
pNGAL at 24h for AKI occurrence at 48 or 72 h	125	400	0.79 (0.54-0.94)	0.75 (0.64 -0.81)	0.93	0.8807
pNGAL at 48h for AKI occurrence at 72 h	77	400	0.73 (0.30-0.94)	0.95 (0.84-0.99)	0.92	0.8723
uNGAL at 0h hours for AKI occurrence at 24, 48 or 72 h	163	350	0.58 (0.39-0.75)	0.84 (0.76-0.90)	0.87	0.7914
uNGAL at 24h for AKI occurrence at 48 or 72 h	118	350	0.75 (0.48- 0.93)	0.82 (0.71-0.9)	0.94	0.7768
uNGAL at 48h for AKI occurrence at 48 or 72 h	68	350	0.75 (0.35-0.97)	0.88 (0.72- 0.97)	0.93	0.8220

NGAL, neutrophil gelatinase-associated lipocalin; AKI, acute kidney injury; CI, confidence interval; NPV, negative predictive value; AUROC, area under the receiver operator characteristic curve; pNGAL, plasma neutrophil gelatinase-associated lipocalin; uNGAL, urine neutrophil gelatinase-associated lipocalin.

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