Table 2 Characteristics of the studies included in the meta-analysis
From: Protective mechanical ventilation in the non-injured lung: review and meta-analysis
Protective ventilation | Standard ventilation | |||||||
|---|---|---|---|---|---|---|---|---|
First author, Year [Ref] | Number of patients | VT (ml/kg) | N | VT (ml/kg) | N | Setting | Design | Primary outcome |
Lee 1990 [31] | 103 | 6 | 47 | 12 | 56 | ICU | RCT | Duration of MV |
Chaney 2000 [14] | 25 | 6 | 12 | 12 | 16 | Surg | RCT | Lung mechanics |
Wrigge 2004 [18] | 62 | 6 | 30 | 12 | 32 | Surg | RCT | Cytokines in BAL |
Koner 2004 [15] | 44 | 6 | 15 | 10 | 29 | Surg | RCT | Cytokines in blood |
Wrigge 2005 [16] | 44 | 6 | 22 | 12 | 22 | Surg | RCT | Cytokines in BAL |
Zupancich 2005 [17] | 40 | 8 | 20 | 10 | 20 | Surg | RCT | Cytokines in BAL |
Michelet 2006 [43] | 52 | 5 | 26 | 9 | 26 | Surg | RCT | Cytokines in blood |
Cai 2007 [27] | 16 | 6 | 8 | 10 | 8 | Surg | RCT | Atelectasis |
Wolthius 2008 [19] | 40 | 6 | 21 | 12 | 19 | Surg | RCT | Pulmonary Inflammation |
Determan 2008 [26] | 40 | 6 | 21 | 12 | 19 | Surg | RCT | Cytokines in BAL |
Weingarten 2010 [20] | 40 | 6 | 20 | 10 | 20 | Surg | RCT | Oxygenation |
Determann 2010 [33] | 150 | 6 | 76 | 10 | 74 | ICU | RCT | Cytokines in BAL |
Pinheiro de Oliveira 2010 [32] | 20 | 6 | 10 | 12 | 10 | ICU | RCT | Cytokines in BAL |
Sundar 2011 [28] | 149 | 6 | 75 | 10 | 74 | Surg | RCT | Duration of MV |
Treschan 2012 [23] | 101 | 6 | 50 | 12 | 51 | Surg | RCT | Spirometry |
Severgnini 2013 [24] | 55 | 7 | 27 | 9 | 28 | Surg | RCT | Change in mCPIS |
Futier 2013 [25] | 400 | 6-8 | 200 | 10-12 | 200 | Surg | RCT | Pulmonary and extrapulmonary complications |