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Table 4 Patient population stratified by adequacy of empirical antimicrobial therapy

From: Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study

 

Adequate AT (n = 587)

Inadequate AT (n = 423)

P value

Age

70 (58 to 77)

69 (57 to 76.2)

0.458

Infection

  

0.048

 Community acquired

276 (47%)

166 (39.2%)

 

 ICU/IMC acquired

144 (24.5%)

117 (27.7%)

 

 Hospital acquired

167 (28.4%)

140 (33.1%)

 

28-day mortality

178 (30.3%)

173 (40.9%)

<0.001

SOFA score

9 (7 to 12)

10 (8 to 12)

0.002

ICU length of stay

8.5 (4 to 22)

14 (5 to 28)

<0.001

Lactate maximum (mmol/l)

2.5 (1.5 to 4.7)

2.9 (1.6 to 5)

0.09

Procalcitonin (ng/ml)

6.3 (1.7 to 21)

6.6 (1.9 to 27.9)

0.497

  1. Inadequacy was defined as escalation of AT within 5 days. Categorical data are expressed as absolute and relative frequencies (number (percentage)) and are compared by the Pearson test; continuous data are expressed as median (interquartile range) and are compared by the Kruskal–Wallis test. SOFA score, lactate, and procalcitonin refer to the day of sepsis onset. AT, antimicrobial therapy; IMC, intermediate care ward; SOFA, Sequential Organ Failure Assessment.
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