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Table 2 Data on microcirculation, tissue oxygenation, hemodynamics, blood gas analysis and fluid balance

From: Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial

Parameter

Group

M 0

M 1

M 2

M 3

M 4

M 5

M 6

M 7

M 8

Tissue oxygenation(tpO 2 mmHg)

1 (TEA)

63.8 ± 14.1

40.2 ± 17.7

32.5 ± 11.4

36.3 ± 13.7

37.1 ± 12.2

36.8 ± 11.0

36.2 ± 10.5

35.2 ± 9.1

35.0 ± 9.1

2 (Control)

64.2 ± 14.1

45.2 ± 21.4

32.4 ± 16.2

25.7 ± 15.9*

22.8 ± 15.6*

22.2 ± 15.9*

20.4 ± 15.0*

20.5 ± 14.3*

20.4 ± 14.2*

Microcirculation(Flux AU)

1 (TEA)

391.9 ± 82.8

253.3 ± 81.2

236.1 ± 55.1

288.9 ± 73.4

300.4 ± 68.5

276.2 ± 65.7

254.1 ± 73.8

249.9 ± 66.0

241.5 ± 97.0

2 (Control)

408.5 ± 88.3

267.4 ± 103.4

233.2 ± 56.3

215.9 ± 104.9*

201.8 ± 108.1*

182.4.0 ± 90.0*

168.6 ± 89.0*

160.5 ± 80.7*

150.6 ± 85.7*

HR (min -1 )

1 (TEA)

90.5 ± 24.9

91.9 ± 24.5

95.4 ± 21.5

94.4 ± 19.9

97.7 ± 16.8

100.7 ± 16.3

99.4 ± 14.6

99.3 ± 10.3

99.4 ± 13.2

2 (Control)

85.5 ± 13.8

85.4 ± 14.9

91.1 ± 16.6

95.5 ± 16.7

98.9 ± 15.0

101.0 ± 13.8

103.3 ± 14.7

102.6 ± 16.5

100.8 ± 11.3

MAP (mmHg)

1 (TEA)

72.5 ± 10.6

74.1 ± 11.5

76.8 ± 10.6

74.8 ± 8.7

74.9 ± 8.4

70.9 ± 7.2

67.2 ± 6.6

64.1 ± 5.3

62.2 ± 6.2

2 (Control)

74.7 ± 10.4

73.3 ± 8.3

73.5 ± 9.4

73.4 ± 7.7

73.1 ± 11.2

69.6 ± 5.8

66.5 ± 6.7

64.2 ± 6.2

61.9 ± 6.8

CI (L/min)

1 (TEA)

4.7 ± 1.3

4.9 ± 1.3

5.2 ± 1.1

5.1 ± 0.9

5.0 ± 0.9

5.2 ± 0.9

4.8 ± 0.7

4.6 ± 0.5

4.7 ± 0.8

2 (Control)

4.6 ± 0.8

4.6 ± 0.8

5.1 ± 1.1

5.1 ± 0.8

5.1 ± 0.9

5.1 ± 0.9

5.2 ± 1.0

5.2 ± 1.1

5.2 ± 0.9

SVV (%)

1 (TEA)

6.5 ± 2.7

6.2 ± 1.1

5.9 ± 1.0

5.9 ± 1.0

7.1 ± 1.9

7.1 ± 1.5

6.5 ± 1.5

7.1 ± 1.5

7.3 ± 1.5

2 (Control)

6.6 ± 1.6

6.8 ± 1.6

6.1 ± 1.3

6.1 ± 1.3*

6.9 ± 1.8*

6.6 ± 0.9*

6.2 ± 1.6*

6.8 ± 1.7*

7.2 ± 2.6*

CVP (mmHg)

1 (TEA)

6.7 ± 1.9

6.6 ± 1.7

7.0 ± 1.9

6.6 ± 2.3

6.5 ± 2.2

6.4 ± 1.7

6.6 ± 1.8

6.7 ± 1.6

6.6 ± 1.9

2 (Control)

7.2 ± 2.4

6.6 ± 1.9

7.1 ± 2.0

7.0 ± 1.7

7.1 ± 2.0

7.2 ± 2.2

7.8 ± 2.3

7.5 ± 2.6*

8.1 ± 2.9*

p a O 2 (mmHg)

1 (TEA)

161.1 ± 67.7

147.8 ± 24.9

139.1 ± 14.7

137.1 ± 12.7

134.7 ± 16.5

131.1 ± 17.6

130.2 ± 18.0

126.8 ± 17.2

125.3 ± 17.3

2 (Control)

159.2 ± 21.2

145.4 ± 16.8

141.1 ± 14.9

138.6 ± 16.7

128.8 ± 12.7

124.8 ± 18.2

122.4 ± 17.1

118.4 ± 16.6

115.9 ± 18.7

ScvO 2 (%)

1 (TEA)

72.8 ± 8.4

75.2 ± 8.3

73.9 ± 10.8

74.4 ± 11.7

73.6 ± 13.2

71.6 ± 12.6

71.3 ± 9.6

69.1 ± 9.3

65.6 ± 12.9

2 (Control)

81.6 ± 9.9

77.5 ± 9.6

79.4 ± 9.8

77.3 ± 9.4

70.8 ± 12.3

73.6 ± 12.2

73.4 ± 11.0

74.8 ± 11.5

72.0 ± 12.5

Lactate(mmol/L)

1 (TEA)

0.9 ± 0.3

0.8 ± 0.2

0.8 ± 0.2

0.9 ± 0.2

0.8 ± 0.2

0.8 ± 0.2

0.7 ± 0.2

0.7 ± 0.2

0.7 ± 0.2

2 (Control)

0.9 ± 0.3

0.9 ± 0.4

0.9 ± 0.4

0.9 ± 0.4

0.8 ± 0.3

0.7 ± 0.2

0.6 ± 0.2

0.6 ± 0.2

0.6 ± 0.2

Colloids (ml)

1 (TEA)

59 ± 141

121 ± 193

397 ± 235

518 ± 203

676 ± 290

879 ± 367

1.088 ± 434

1.294 ± 460

1.594 ± 560

2 (Control)

0 ± 0

50 ± 132

174 ± 209

388 ± 172

538 ± 156

768 ± 225

1.032 ± 171

1.382 ± 269

1.694 ± 420

Cristalloids (ml)s

1 (TEA)

757 ± 210

1047 ± 325

1.268 ± 403

1.518 ± 460

1.844 ± 548

2.347 ± 637

2.756 ± 748

3.232 ± 968

3.606 ± 1.103

2 (Control)

621 ± 211

932 ± 292

1.271 ± 335

1.415 ± 363

1.829 ± 357

2.276 ± 370

2.788 ± 501

3.300 ± 663

0.3800 ± 794

Urine (ml)

1 (TEA)

297 ± 271

406 ± 370

579 ± 491

682 ± 552

1.012 ± 702

1.294 ± 833

1.571 ± 1.015

1.868 ± 1.166

2.188 ± 1.343

 

2 (Control)

206 ± 228

335 ± 337

582 ± 559

762 ± 644

1.065 ± 748

1.424 ± 858

1.876 ± 1.013

2.376 ± 1.136

2.844 ± 1.305

  1. Values for tissue oxygenation (tpo2 (mmHg)), microcirculatory flow (Flux (AU)), Heart rate (HR (min-1)), mean arterial pressure (MAP (mmHg)), cardiac index (CI (L/min)), systemic vascular resistance (SVRi (dynes*sec/cm5/m2)), stroke volume variation (SVV (%)), central venous pressure (CVP (mmHg)), arterial partial oxygen pressure (paO2 (mmHg)), central venous oxygen saturation (ScvO2 (%)), lactate measured in arterial blood gas analysis (mmol/L), cumulative crystalloid infusion (ml), cumulative colloid infusion (ml) and urine output (ml). Data are presented as mean ± standard deviation. *represents statistically significant differenence between treatment groups (P <0.05) at time of measurement. M 0: before induction of the acute pancreatitis, M 1 and 2: after induction of the acute pancreatitis, M 2 to 8: during treatment interval. TEA, thoracic epidural anesthesia.
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