Table 3 Changes of the increase rate of left intraventricular systolic pressure (mmHg/second)

6 weeks old

Female

  No treatment

5,454.1 ± 717.6

2,474.2 ± 325.5

2,371.1 ± 311.9

2,272.3 ± 298.9

2,177.6 ± 286.5

  40 mmHg

5,461.8 ± 718.6

2,477.2 ± 325.9

3,400.0 ± 578.9**

4,569.5 ± 601.2**

5,045.9 ± 663.9**

  50 mmHg

5,905.4 ± 1,362.2

2,314.5 ± 1,114.4

4,663.8 ± 918.0**#

4,777.2 ± 903.7**

5,275.2 ± 601.9**

  60 mmHg

5,476.4 ± 720.5

2,482.9 ± 326.7

4,602.1 ± 605.5**#

4,453.3 ± 585.9**

4,878.6 ± 641.9**

  70 mmHg

5,410.0 ± 788.7

2,456.9 ± 645.3

4,776.7 ± 1,111.0**#

4,420.9 ± 1,015.7**

4,821.9 ± 932.0**

  80 mmHg

5,547.3 ± 729.9

2,510.8 ± 330.3

4,525.3 ± 595.4**#

4,188.2 ± 551.0**

4,568.2 ± 601.0**#

Male

  No treatment

5,417.0 ± 712.7

2,118.5 ± 278.7

2,030.2 ± 267.1

1,945.7 ± 256.0

1,864.6 ± 245.3

  40 mmHg

5,424.8 ± 713.7

2,121.2 ± 279.1

3,519.6 ± 528.9**

4,404.9 ± 579.6**

4,943.3 ± 650.4**

  50 mmHg

5,938.1 ± 833.1

2,013.5 ± 681.6

4,278.2 ± 538.1**

4,605.2 ± 398.8**

5,168.0 ± 459.9**

  60 mmHg

5,439.4 ± 715.7

2,126.1 ± 279.7

4,251.1 ± 559.3**

4,525.9 ± 595.5**

4,842.5 ± 637.1**

  70 mmHg

5,372.7 ± 638.0

2,103.5 ± 522.0

4,328.0 ± 386.0**

4,518.0 ± 499.0**

4,796.0 ± 558.0**

  80 mmHg

5,510.8 ± 725.1

2,150.3 ± 282.9

4,100.2 ± 539.5**

4,280.2 ± 563.1**

4,543.5 ± 597.8**

14 weeks old

Female

  No treatment

5,925.4 ± 779.6

2,750.0 ± 361.8

2,635.4 ± 346.7

2,525.6 ± 332.3

2,420.3 ± 318.4

  40 mmHg

5,933.7 ± 780.7

2,753.5 ± 362.3

3,491.2 ± 590.9**

5,068.1 ± 666.8**

4,898.9 ± 644.6**

  50 mmHg

6,369.5 ± 1,402.5

2,654.6 ± 1,147.7

4,232.5 ± 731.3**

5,298.4 ± 930.4**

5,121.6 ± 268.0**

  60 mmHg

5,949.4 ± 782.8

2,760.0 ± 363.1

4,852.7 ± 638.5**

4,943.2 ± 650.4**

4,932.7 ± 649.0**

  70 mmHg

5,877.8 ± 927.1

2,730.2 ± 758.5

4,392.3 ± 1,007.3**

4,907.7 ± 1,578.3**

4,905.7 ± 1,407.8**

  80 mmHg

6,026.0 ± 792.8

2,791.9 ± 367.3

4,161.1 ± 547.5**

4,649.4 ± 611.7**

4,647.5 ± 611.5**

Male

  No treatment

6,689.7 ± 880.2

2,321.2 ± 305.4

2,224.5 ± 292.7

2,131.8 ± 280.5

2,042.9 ± 268.8

  40 mmHg

6,698.2 ± 881.3

2,324.1 ± 305.8

3,379.9 ± 576.3**

4,696.6 ± 617.9**

4,592.4 ± 604.2**

  50 mmHg

6,495.3 ± 1,417.3

2,231.5 ± 660.0

4,660.1 ± 413.9**#

4,910.0 ± 910.3**

4,801.1 ± 645.3**

  60 mmHg

6,714.2 ± 883.4

2,329.6 ± 306.5

4,814.1 ± 633.4**#

4,674.9 ± 615.1**

4,693.2 ± 617.5**

  70 mmHg

6,641.3 ± 849.6

2,304.5 ± 695.1

4,224.5 ± 944.6**

4,651.4 ± 823.9**

4,677.8 ± 563.1**

  80 mmHg

6,792.3 ± 893.7

2,356.4 ± 310.0

4,002.1 ± 526.6**

4,406.6 ± 579.8**

4,431.6 ± 583.1**

1.5 years old

Female

  No treatment

6,664.3 ± 876.8

2,777.2 ± 365.4

2,661.5 ± 350.2

2,550.6 ± 335.6

2,444.3 ± 321.6

  40 mmHg

6,672.2 ± 877.9

2,780.9 ± 365.9

3,398.3 ± 447.1**#

4,711.4 ± 619.9**

5,625.3 ± 740.1**

  50 mmHg

6,002.8 ± 1,707.0

2,803.2 ± 1,397.9

4,230.9 ± 594.2**##

5,104.0 ± 1,121.5**

6,094.0 ± 931.6**

  60 mmHg

6,687.0 ± 879.8

2,787.8 ± 366.8

4,492.9 ± 591.1**##

5,208.6 ± 685.3**

6,307.0 ± 829.8**

  70 mmHg

6,619.5 ± 1,166.2

2,756.3 ± 954.1

4,710.4 ± 827.6**##

5,295.4 ± 1,312.6**

6,483.7 ± 1,638.6**

  80 mmHg

6,759.1 ± 889.3

2,821.5 ± 371.2

4,462.5 ± 587.1**##

5,016.7 ± 660.1**

6,142.5 ± 808.2**

Male

  No treatment

5,961.5 ± 784.4

2,618.5 ± 344.5

2,509.4 ± 330.2

2,404.9 ± 316.4**

2,304.7 ± 303.2**

  40 mmHg

5,969.8 ± 785.5

2,622.0 ± 345.0

3,418.3 ± 449.7**

4,787.5 ± 629.9**

5,711.2 ± 751.4**

  50 mmHg

6,400.8 ± 1,410.1

2,654.6 ± 1,154.0

4,445.3 ± 761.2**

5,186.4 ± 1,559.6**

6,187.1 ± 1,311.6**

  60 mmHg

5,985.6 ± 787.5

2,628.6 ± 345.8

4,719.6 ± 621.0**#

5,197.9 ± 683.9**

6,296.6 ± 828.5**

  70 mmHg

5,913.7 ± 1,381.5

2,598.7 ± 1,130.8

4,947.3 ± 1,040.2**#

5,207.4 ± 781.8**

6,387.5 ± 1,125.5**

  80 mmHg

6,062.6 ± 797.7

2,660.5 ± 350.0

4,686.9 ± 616.7**#

4,933.3 ± 649.1**

6,051.3 ± 796.2**