Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function

Table 1 Administered treatment, fluid output and balance during the study

Variables/Study group	Septic-CG	Low-MAP	High-MAP	P-value
Propofol, mg/kg/h	5.0 ± 1.0	5.8 ± 0.7	5.8 ± 0.5	0.11^a
Fentanyl, mcg/kg/h^†	4.0 ± 1.6	3.9 ± 0.8	4.4 ± 0.9	0.62^a
Midazolam, mg/kg/h	0.08 ± 0.03	0.06 ± 0.02	0.07 ± 0.04	0.38^a
Fluid bolus, mL/kg/h^††*
Median		0.7	2.0	0.06^b
IQR		0.5, 2.0	1.6, 2.8
Norepinephrine
Number/number in group (%)		3/8 (37.5)	8/8 (100.0)	0.026^c
Median dose, mcg/kg/min		0.00	0.38	0.009^b
IQR		0.00, 0.25	0.21, 0.56
Dobutamine
Number/number in group (%)		4/8 (50.0)	3/8 (37.5)	1.00^c
Median dose, mcg/kg/min		0.06	0.00	0.45^b
IQR		0.00, 3.16	0.00, 1.00
Total volume received, mL/kg/h	1.5 ± 0.0	3.6 ± 0.8^§	4.7 ± 1.4^#	0.001^a
Urine output, mL/kg/h	0.6 ± 0.1	1.0 ± 0.2^§	1.1 ± 0.2^#	0.001^a
Gastric tube output, mL/kg/h	0.3 ± 0.2	0.3 ± 0.3	0.3 ± 0.2	0.95^a
Final balance^╫, mL/kg/h	0.6 ± 0.3	2.3 ± 0.7^§	3.3 ± 1.0^#¥	0.001^a
Final balance^╫, L	0.5 ± 0.4	5.2 ± 1.1^§	6.7 ± 1.4^#¥	0.001^a

Values are mean ± SD or median (IQR) unless stated otherwise. ^†Sum of basic fentanyl infusion with additional boluses; *administered during the 48-h resuscitation period; ^††sum of Ringer's lactate and hydroxyethyl starch; ^╫final balance = (Ringer's Lactate basal infusion + glucose 50% basal infusion + Ringer's lactate bolus + hydroxyethyl starch bolus) - (urine output + gastric tube output); ^aone-way analysis of variance (ANOVA). Tukey post hoc test after ANOVA, comparisons significant at the 0.05 level: ^¥low-mean arterial pressure (MAP) versus high-MAP; ^§low-MAP versus septic control group (Septic-CG); ^#high-MAP versus Septic-CG; ^bMann-Whitney test; ^cFisher's exact test.

ISSN: 1364-8535