Elevated troponin I and its prognostic significance in acute liver failure

Table 4 Results of multivariate analysis of predictors of outcome.

Variable	Odds ratio	95% CI	P value	Odds ratio	95%CI	P value
Age	1.016	0.998-1.034	0.077
Gender (M:F)	0.934	0.549-1.591	0.803
Troponin	1.032	0.974-1.094	0.281
Troponin positive	1.493	0.862-2.593	0.152
Troponin high	1.674	0.947-2.761	0.077
LVF (Y/N)	0761	0.271-2.174	0.617
ALF/SALF	5.907	2.481-14.064	< 0.001	-	-	-
Ischaemic Aetiology	0.572	0.181-1.808	0.341
AST	1.000	0.999-1.000	0.2379
Peak AST	1.000	0.999-1.000	0.857
Bilirubin	1.002	1.000-1.004	0.029	1.003	1.000-1.006	0.039
Albumin	0.953	0.872-1.042	0.289
Urea	0.936	0.817-1.072	0.341
Creatinine	0.998	0.996-1.007	0.168
CVVHF	2.580	1.400-4.74	0.001
INR	1.264	1.154-1.385	< 0.001	1.263	1.096-1.455	0.001
pH	0.037	0.001-1.407	0.064
Lactate	1.296	1.132-1.481	< 0.001	1.547	1.137-2.105	0.005
Heart rate	1.019	1.000-1.021	0.046
MAP	0.967	0.952-0.982	< 0.001
CI	1.127	0.784-1.618	0.516
ITBVI	0.996	0.997-1.001	0.708
EVLWI	1.009	0.921-1.105	0.840
CVP	1.108	1.009-1.214	0.025
SVO2	1.015	0.965-1.065	0.546
Inotropes (Y:N)	5.463	2.946-10.182	< 0.001
CK	1.000	0.999-1.000	0.596
Invasive ventilation	2.234	1.250-3.999	0.006
pO2	0.897	0.815-0.984	0.018
FiO2	8.392	1.502-46.79	0.009
pO2/FiO2 ratio	0.946	0.946-0.982	< 0.001
NH4	1.007	1.002-1.013	0.005
HE Grade	2.471	1.812-3.654	< 0.001	3.293	1.895-5.723	< 0.001
MELD	1.130	1.071-1.198	< 0.001	-
APACHE 2	1.081	1.042-1.124	< 0.001	-
SAPS	1.038	1.021-1.055	< 0.001	-
SOFA	1.168	1.088-1.254	< 0.001	-

The multivariate analysis is for the ALF cohort only given the low numbers of SALF patients. The independent multivariate predictors are on the right. This model would correctly classify 80% of patients with an AUROC of 0.84 (0.79 to 0.89, P < 0.001). ALF, acute liver failure; APACHE, Acute Physiology and Chronic Health Evaluation; AST, aspartate transaminase; CI, confidence interval; CK, creatinine kinase; CVP, central venous pressure; CVVHF, continuous venovenous haemofiltration; FiO2, fraction of inspired oxygen; HE, hepatic encephalopathy; INR. international normalised ratio; MAP, mean arterial pressure; MELD, model for end stage liver disease; NH4, ammonia; pO2, partial pressure of oxygen; SALF, subacute liver failure; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; SV02, central venous saturation.

ISSN: 1364-8535