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Table 3 Univariate and multivariable logistic regression analysis of mortality at the time first organ failure is diagnosed.

From: Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: a prospective cohort study

  

Univariate

Multivariable

Risk factor

N

Crude OR

(95% CI)

P value

Adjusted OR

(95% CI)

P value

Predisposition

     

Age

159

1.02 (0.98, 1.05)

0.324

  

Gender (M/F)

159

0.72 (0.35, 1.48)

0.375

  

Aetiology alcohol

159

1.42 (0.71, 2.86)

0.325

  

PT (sec)

128

1.44 (1.23, 1.68)

< 0.0001

  

INR (per unit)

159

8.94 (3.12, 25.66)

< 0.0001

6.43 (1.82, 22.71)

0.004

aPTT (sec)

132

1.04 (1.01, 1.06)

0.001

  

Bilirubin (per 10 umol/L)

158

1.03 (1.02, 1.05)

< 0.0001

1.04 (1.02, 1.07)

0.001

Albumin (g/L)

145

0.94 (0.89, 0.99)

0.027

  

Creatinine

(per 10 umol/L)

148

1.04 (1.00, 1.07)

0.028

  

Child score

152

1.91 (1.51, 2.41)

< 0.0001

  

MELD score

146

1.09 (1.05, 1.14)

< 0.0001

  

Hospitalisation within last 6 months

159

4.92 (2.42, 10.00)

< 0.0001

4.97 (1.89, 13.09)

0.001

Injury

     

Infection

159

1.88 (0.99, 3.56)

0.053

  

Variceal bleed

159

0.66 (0.33, 1.32)

0.237

  

Alcohol binge

159

0.66 (0.35, 1.26)

0.210

  

Dehydration

159

1.92 (0.70, 5.25)

0.202

  

Drugs

159

0.35 (0.03, 3.92)

0.393

  

Response

     

SIRS score

158

1.38 (1.00, 1.91)

0.051

  

Infection

152

3.05 (1.43, 6.49)

0.004

  

Organ failure

     

Inotrope

152

18.81 (5.49, 64.45)

< 0.0001

14.70 (3.18, 68.03)

0.001

Renal failure

153

6.09 (2.86, 12.97)

< 0.0001

3.46 (1.18, 10.12)

0.023

Haemofiltration

152

5.96 (2.45, 14.53)

< 0.0001

  

Mechanical ventilation

152

5.42 (2.45, 11.98)

< 0.0001

  

Hepatic encephalopathy

159

0.88 (0.46, 1.66)

0.690

  

Hyperbilirubinemia > 340 umol/l

159

3.87 (1.76, 8.52)

0.001

  

Severe coagulopathy

144

13.24 (1.70, 103.20)

0.014

  

APACHE II score

114

1.12 (1.04, 1.20)

0.002

  

SOFA score

153

1.51 (1.29, 1.77)

< 0.0001

  
  1. Due to different amount of missing data and correlations among predictors, stepwise selection was done manually to build the multivariable model. 151 observations were included in the final multivariable analysis. The scores (Child, MELD, SOFA, APACHE II) were not incorporated into the multivariable analysis. APACHE II, Acute Physiology, Age and Chronic Health Evaluation; aPTT, activated partial thromboplastin time; CI, confidence interval; INR, international normalised ratio; MELD, Model for End-Stage Liver Disease; OR, odds ratio; PT, prothrombin time; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sepsis Organ Failure Assessment.
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