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Table 2 Differences between survivors and non-survivors at the time first organ failure is diagnosed.

From: Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: a prospective cohort study

 

Survivors

(n= 66)

Non-survivors

(n= 93)

Predisposition

  

Age

51.1 ± 1.1

52.5 ± 0.9

Gender (M/F)

47/19

72/21

Aetiology alcohol N (%)

45 (68)

70 (75)

PT (sec)

15.9 ± 0.4***

20.7 ± 0.6

INR

1.54 ± 0.04**

1.91 ± 0.06

aPTT (sec)

49.9 ± 2.0***

65.5 ± 3.4

Bilirubin (umol/L)

190.6 ± 20.0***

331.2 ± 25.4

Albumin (g/L)

27.3 ± 0.9**

24.8 ± 0.7

Creatinine (umol/L)

114.8 ± 13.3***

170.5 ± 16.9

Child

10.1 ± 0.2***

12.1 ± 0.2

MELD

12.0 ± 1.0***

19.6 ± 1.1

Hospitalisation within last 6 months N (%)

15 (23)

55 (59)

Injury

  

Infection N (%)

28 (42)

54 (58)

Variceal bleed N (%)

22 (33)

23 (24)

Alcohol binge N (%)

40 (60)

47 (51)

Dehydration N (%)

6 (9)

15 (16)

Drugs N (%)

2 (3)

1 (1)

Response

  

SIRS N (%)

25 (38)

46 (49)

Infection N (%)

12 (18)**

38 (41)

Organ failure

  

Inotrope N (%)

3 (5)***

44 (47)

Renal failure N (%)

12 (18)***

53 (57)

Haemofiltration N (%)

7 (11)***

38 (41)

Mechanical ventilation N (%)

10 (15)***

45 (48)

Hepatic encephalopathy

39 (59)

52 (56)

Hyperbilirubinemia > 340 umol/l

10 (15)***

38 (41)

Severe coagulopathy

1 (2)**

15 (18)

APACHEII

10.9 ± 0.8*

15.1 ± 0.8

SOFA

6.7 ± 0.3**

9.4 ± 0.3

  1. *P < 0.05; **P < 0.005; ***P < 0.001; data expressed as mean (SEM). APACHE II, Acute Physiology, Age and Chronic Health Evaluation; aPTT, activated partial thromboplastin time; INR, international normalised ratio; MELD, Model for End-Stage Liver Disease; PT, prothrombin time; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sepsis Organ Failure Assessment.