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Table 1 Demographic and clinical characteristics of the patients

From: Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality

 

Global

n= 1,372

Community-acquired

n= 1,022 (74.5%)

Nosocomial

n= 350 (25.5%)

P

General data

Sex (male)

837 (61%)

623 (61%)

214 (61%)

0.999

Age (years)

62.24 ± 16.22

62.00 ± 16.65

62.93 ± 14.87

0.354

APACHE II

21.44 ± 7.54

21.09 ± 7.49

22.45 ± 7.61

0.004

Lactate (mM)

35.56 ± 26.94

36.76 ± 27.68

32.06 ± 24.37

0.020

Diagnosis on admission

Medical

893 (65.4%)

734 (72%)

159 (45.8%)

 

Trauma

25 (1.8%)

8 (0.8%)

17 (4.9%)

<0.001

Emergency surgery

382 (28%)

256 (25.1%)

126 (36.3%)

 

Elective surgery

66 (4.86%)

21 (2.1%)

45 (13%)

 

Type of infection

Pneumonia

502 (36.6%)

362 (35.4%)

140 (40%)

 

Abdominal

390 (28.4%)

270 (26.4%)

120 (34.3%)

 

Urologic

182 (13.3%)

163 (15.9%)

19 (5.4%)

 

Meningitis

50 (3.6%)

47 (4.6%)

3 (0.9%)

<0.001

SSTI

54 (3.9%)

46 (4.5%)

8 (2.3%)

 

Catheter

24 (1.7%)

6 (0.6%)

18 (5.1%)

 

Others

138 (3.1%)

108 (10.6%)

30 (8.6%)

 

More than one focus

32 (2.3%)

20 (2.0%)

12 (3.4%)

 

Organ failure

Hemodynamic

1,129 (82.3%)

845 (82.7%)

284 (81.1%)

0.517

Respiratory

880 (64.1%)

641 (62.7%)

239 (68.3%)

0.062

Renal

,1006 (73.3%)

754 (73.8%)

252 (72.0%)

0.529

Hepatic

238 (17.3%)

176 (17.2%)

62 (17.7%)

0.870

Hematologic

344 (25.1%)

266 (26.0%)

78 (22.3%)

0.175

Coagulation

502 (36.6%)

394 (38.6%)

108 (30.9%)

0.010

Mortality

526 (38.3%)

356 (34.8%)

170 (48.6%)

<0.001