Table 4 Most frequently used doses and schedules of antibiotic and antifungal drugs.
From: A survey on infection management practices in Italian ICUs
Drug/Administration | Frequency Number (%)a | Drug/Administration | Frequency Number (%)a |
|---|---|---|---|
Vancomycin | Â | Ceftazidime | Â |
   TDD: 2 g | 104/142 (73) |    TDD: 6 g | 89/141 (63) |
   Infusion: Continuous | 122/142 (86) | 3 g | 20/141 (14) |
   Other: TDM | 94/142 (66) |    Infusion: Continuous | 68/141 (48) |
|  |  |    Schedule: 3 doses/day | 64/141 (45) |
Teicoplanin | Â | Ceftriaxone | Â |
   TDD: 400 mg | 43/110 (39) |    TDD: 2 g | 72/141 (51) |
800 mg | 32/110 (29) | 4 g | 45/141 (32) |
   Loading dose | 86/90 (96) |    Schedule: 2 doses/day | 78/141 (55) |
| Â | Â | Once daily | 64/141 (45) |
Piperacillin/tazobactam | Â | Cefepime | Â |
   TDD: 18.0 g | 61/148 (41) |    TDD: 6 g | 51/141 (36) |
13.5 g | 41/148 (28) | 4 g | 28/141 (20) |
   Infusion: Intermittent | 61/148 (41) |    Schedule: 3 doses/day | 75/141 (53) |
Continuous | 55/148 (37) | 2 doses/day | 66/141 (47) |
Prolonged (3-4 hours) | 33/148 (22) | Â | Â |
Meropenem | Â | Levofloxacin b | Â |
   TDD: 3 g | 62/138 (45) |    TDD: 1000 mg | 81/139 (58) |
6 g | 26/138 (19) | 750 mg | 33/139 (24) |
Infusion: Prolonged intermittent | 65/138 (47) |    Schedule: 2 doses/day | 90/139 (65) |
Intermittent infusion | 55/138 (40) | Once daily | 49/139 (35) |
Continuous infusion | 18/138 (13) | Â | Â |
Imipenem | Â | Ciprofloxacin b | Â |
   TDD: 2 g | 66/135 (49) |    TDD: 1200 mg | 61/138 (44) |
3 g | 28/135 (21) | 800 mg | 44/138 (32) |
   Schedule: 4 doses/day | 99/135 (73) |    Schedule: 2 doses/day | 70/138 (51) |
3 doses/day | 36/135 (27) | 3 doses/day | 68/138 (49) |
Amikacin | Â | Fluconazole | Â |
   TDD: 1 g | 65/120 (54) |    TDD: 400 mg | 77/137 (56) |
1.5 g | 13/120 (11) | 800 mg | 25/137 (18) |
   Schedule: Once daily | 106/120 (88) |    Schedule: Once daily | 104/137 (76) |
| Â | Â | 2 doses/day | 33/137 (24) |
|  |  |    Loading dose | 114/137 (83) |
Gentamicin | Â | Voriconazole | Â |
   TDD: 240 mg | 35/120 (29) |    TDD: 8 mg/kg | 56/137 (41) |
160 mg | 18/120 (15) | 4 mg/kg | 27/137 (20) |
   Schedule: Once a day | 106/120 (88) |    Loading dose | 125/137 (91) |
Daptomycin | Â | Anidulafungin | Â |
   TDD: 6 mg/kg | 70/137 (51) |    TDD: 100 mg | 94/124 (76) |
8 mg/kg | 29/137 (21) |    Loading dose | 119/124 (96) |
Linezolid | Â | Caspofungin | Â |
   TDD: 1200 mg | 128/132 (97) |    TDD: 50 mg | 114/127 (90) |
   Infusion: Intermittent | 111/132 (84) |    Loading dose | 126/127 (99) |
Tigecycline | Â | Micafungin | Â |
   TDD: 100 mg | 130/134 (97) |    TDD: 100 mg | 105/128 (82) |
   Schedule: 2 doses/day | 133/134 (99) |  |  |
   Loading dose | 131/134 (98) |  |  |
Colistin | Â | Amphotericin B | Â |
   Intravenous |  |    TDD: |  |
TDD: 6,000,000 IU | 29/107(27) |    Liposomal |  |
9,000,000 IU | 27/107 (25) | 3 mg/kg | 61/127 (48) |
Schedule: 3 times/day | 65/107 (61) | 5 mg/kg | 48/127 (38) |
Loading dose | 48/107 (45) |    Lipid complex |  |
   Aerosol |  | 5 mg/kg | 54/101 (53) |
TDD: 3,000,000 IU | 36/107 (34) | 3 mg/kg | 29/101 (29) |
Schedule: 3 times/day | 61/107 (57) | Â | Â |