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Figure 1 | Critical Care

Figure 1

From: Noradrenergic neurons regulate the egress and trafficking of splenic monocytes and influence mortality during Gram-negative infection in mice

Figure 1

Nonadrenergic nerve ablation with 6-OHDA improves survival during K. pneumonia intraperitoneal sepsis (A). Nonadrenergic nerve ablation leads to improved bacterial killing (B) and enhanced monocyte recruitment 4 hours after infection (D). The survival benefit of 6-OHDA treatment required the spleen because splenectomy (SPLX) prior to 6-OHDA treatment abolishes this survival benefit (C). Peritoneal monocytes were quantified 4 hours after infection in 6-OHDA-treated mice with or without spleens (D). 6-OHDA treatment enhanced the recruitment of splenic monocytes to the peritoneum during infection (D). *P < 0.05.

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Critical Care

ISSN: 1364-8535