Mannitol increases renal blood flow and maintains filtration fraction and oxygenation in postoperative acute kidney injury: a prospective interventional study

Table 4 Effects of mannitol on renal variables

	C1	C2	M1	M2	P value
RBF (ml/min)	472 ± 48	465 ± 44	521 ± 49	503 ± 47	0.016
RVR (mm Hg/ml/min)	0.150 ± 0.018	0.147 ± 0.015	0.132 ± 0.014	0.135 ± 0.014	0.030
GFR (ml/min)	33.8 ± 4.6	36.0 ± 5.56	41.0 ± 7.28	39.2 ± 5.69	0.156
FF	0.104 ± 0.015	0.113 ± 0.016	0.110 ± 0.016	0.103 ± 0.011	0.743
GFNa (mmol/min)	4.82 ± 0.66	5.05 ± 0.82	5.98 ± 1.08	5.61 ± 0.82	0.141
TRNa (mmol/min)	4.45 ± 0.64	4.65 ± 0.79	5.30 ± 1.04	5.00 ± 0.79	0.286
FENa	0.078 ± 0.023	0.089 ± 0.023	0.125 ± 0.025	0.117 ± 0.021	0.008
RVO₂ (ml/min)	10.62 ± 1.25	11.35 ± 1.27	12.1 ± 1.48	11.5 ± 1.30	0.138
RO₂Ex	0.169 ± 0.014	0.174 ± 0.014	0.172 ± 0.016	0.170 ± 0.017	0.940
Urine flow (ml/min)	3.50 ± 0.68	3.58 ± 0.58	6.01 ± 1.09	5.38 ± 0.99	0.004
RBF/CO	0.080 ± 0.009	0.080 ± 0.008	0.088 ± 0.009	0.084 ± 0.008	0.040

Data are presented as mean ± SEM. C1, first control period before mannitol infusion; C2, second control period before mannitol infusion; FENa, fractional excretion of sodium; FF, filtration fraction; GFNa, sodium filtration; GFR, glomerular filtration rate; M1, first period with mannitol infusion (150 mg/ml, infusion rate of 0.5 ml/kg/h); M2, second period with mannitol infusion (150 mg/ml, infusion rate of 0.5 ml/kg/h); RBF, renal blood flow; RO₂Ex, renal oxygen extraction; RVR, renal vascular resistance; RVO₂, renal oxygen consumption; TRNa, sodium reabsorption.

ISSN: 1364-8535