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Table 2 Parameters and laboratory results during renal replacement therapy (RRT).

From: Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts

 

All (n = 232)

SLED (n = 115)

CVVH (n = 117)

P*

Norepinephrine (µ/kg/min)

0.128 ± 0.129

0.137 ± 0.149

0.121 ± 0.11

0.266

Epinephrine (µ/kg/min) (n = 30)

0.100 ± 0.359

0.156 ± 0.233

0.243 ± 0.456

0.273

Dobutamine (µ/kg/min) (n = 109)

2.561 ± 1.446

2.710 ± 1.288

2.425 ± 1.576

0.015

Furosemide dose (mg/24h)

298.4 ± 239.5

311.0 ± 259.2

286.1 ± 218.9

0.365

Urine output (ml/24h)

1945 ± 1647

1860 ± 1693

2027 ± 1605

0.121

Duration of treatment (h)

(values after exclusion of incomplete first and last treatment, see Methods)

16.7 ± 4.8

14.9 ± 4.4

15.9 ± 4.2

(19.9 ± 3.64)

0.024

Average number of treatments

7.67 ± 8.39

7.50 ± 8.89

7.83 ± 7.92

0.096

Absolute number of treatments

1694

817

877

 

Net ultrafiltration (ml/24h)

1730 ± 1099

1850 ± 1179

1617 ± 1008

0.089

Fluid balance (ml/24h)

636 ± 1405

533 ± 1364

736 ± 1443

0.195

Effective blood flow (ml/min)

113.2 ± 15.5

125.7 ± 9.65

101.7 ± 9.82

< 0.001

Effluent flow (ml/h)

  

2390 ± 426

 

Effluent flow rate (ml/kg/h)

  

30.87 ± 7.66

 

Dialysate flow (ml/h)

 

120.9 ± 20.3

  

Body temperature before RRT (°C)

36.5 ± 0.7

36.6 ± 0.7

36.4 ± 0.6

0.002

Change in body temperature during RRT (°C)

-0.2 ± 0.7

-0.3 ± 0.7

- 0.17 ± 0.7

0.011

Heparin (IU/24h)

4874 ± 4004

4554 ± 3594

5191 ± 4438

0.200

Hemoglobin (g/dl)

9.01 ± 0.95

9.06 ± 0.92

8.97 ± 0.97

0.276

Hematocrit (%)

0.29 ± 0.32

0.27 ± 0.03

0.30 ± 0.45

0.237

White blood cell count (/nl)

13.4 ± 7.3

13.0 ± 6.3

13.7 ± 8.2

0.460

Thrombocytes (/nl)

157.8 ± 123.5

157.2 ± 133.5

158.5 ± 113.4

0.177

C-reactive protein (mg/l)

107.5 ± 63.1

110.2 ± 66.8

105.1 ± 59.4

0.392

Albumin (g/l)

23.9 ± 4.6

24.1 ± 4.6

23.7 ± 4.6

0.306

pH

7.38 ± 0.05

7.38 ± 0.06

7.38 ± 0.05

0.242

HCO3- (mmol/l)

23.6 ± 2.55

23.6 ± 2.47

23.6 ± 2.62

0.478

Lactate (mg/dl)

21.1 ± 25.3

19.4 ± 22.9

22.7 ± 27.5

0.260

Serum creatinine pre-treatment (mg/dl)

1.85 ± 0.80

1.77 ± 0.90

1.92 ± 0.68

0.007

Serum creatinine after treatment (mg/dl)

1.46 ± 0.75

1.26 ± 0.80

1.66 ± 0.65

< 0.001

Urea pre-treatment (mg/dl)

113.5 ± 48.3

105.7 ± 55.7

121.2 ± 38.4

0.002

Urea after treatment (mg/dl)

87.1 ± 35.6

68.4 ± 31.2

105.5 ± 29.7

< 0.001

Phosphate pre-treatment (mmol/l)

1.39 ± 1.50

1.42 ± 2.03

1.35 ± 0.52

0.018

Phosphate after treatment (mmol/l)

1.02 ± 0.37

0.88 ± 0.34

1.18 ± 0.35

< 0.001

Calcium (mmol/l)

2.07 ± 0.19

2.04 ± 0.16

2.10 ± 0.22

0.007

Total packed red blood cell Transfusion per patient (ml)

1680 ± 2981

1375 ± 2573

1976 ± 3316

0.019

Total fresh frozen plasma per patient (ml)

1586 ± 4290

1285 ± 3942

1878 ± 4603

0.115

  1. All values are expressed as daily mean (unless otherwise indicated) ± SD; statistical analyses were performed for SLED versus CVVH; *one-tailed Wilcoxon test. SLED: sustained low efficiency dialysis; CVVH: continuous veno-venous hemofiltration.