Without candidemia (number = 1,069) | With candidemia (number = 38) | P value | SDT | |
---|---|---|---|---|
Age, years, mean (SD) | 60.0 ± 17.1 | 59.0 ± 17.9 | .706 | 5.7% |
Male/female (%) | 67.4/32.6 | 63.2/36.8 | .583 | 8.8% |
APACHE II score at ICU admission, mean (SD) | 18.3 ± 7.0 | 20.1 ± 6.5 | .131 | -19.24% |
SOFA score at ICU admission | 7 (4 to 9) | 8.5 (7 to 10) | .004 | |
ICU length of stay (days)a | 17 (12 to 28) | 28.5 (16.5 to 53.5) | .001 | |
Hospital length of stay (days)a | 37 (23 to 59) | 37 (26 to 67) | .436 | |
ICU mortality, number (%) | 220 (20.6) | 20 (52.6)) | < .001 | |
Overall mortality, number (%) | 314 (29.6) | 21 (55.3) | .001 | |
Diagnosis on ICU admission, number (%) | .437 | |||
Medical | 523 (48.9) | 16 (42.1) | -13.68% | |
Surgical | 369 (34.5) | 17 (44.7) | 20.97% | |
Trauma | 177 (16.6) | 5 (13.2) | -9.55 | |
Multifocal colonization, total, number (%) | 649 (60.7) | 35 (92.1) | < .001 | 79.58% |
Clinical condition, number (%) at the time of ICU admission | < .001 | |||
No sepsis | 497 (46.6) | 1 (2.6) | -118.8% | |
Sepsis | 297 (27.9) | 11 (28.9) | 2.22% | |
Severe sepsis | 108 (10.1) | 11 (28.9) | 48.84% | |
Septic shock | 164 (15.4) | 15 (39.5) | 56.1% | |
Surgery, number (%) | 369 (34.4) | 17 (44.7) | .202 | 21.18% |
Abdominal surgery, number (%) | 205 (19.2) | 12 (31.6) | .075 | 28.78% |
Surgical procedures, number | .302 | |||
None | 625 (58.5) | 20 (52.6) | -11.89% | |
One | 316 (29.6) | 10 (26.3) | -7.36% | |
Two or more | 128 (12.0) | 8 (21.1) | 24.67 | |
Secondary peritonitis, number (%) | 65 (6.1) | 4 (10.5) | .306 | 16% |
Underlying illnesses, number (%) | ||||
Neurologic disease | 224 (21.0) | 5 (13.2) | .220 | -20.83% |
Trauma | 197 (18.4) | 7 (18.4) | .999 | 0% |
Diabetes mellitus | 183 (17.1) | 7 (18.4) | .836 | 3.4% |
COPD | 163 (15.2) | 9 (23.7) | .183 | 21.6% |
Heart failure | 91 (8.5) | 6 (15.8) | .155 | 22.48% |
Chronic renal failure | 58 (5.4) | 2 (5.3) | .965 | -0.44% |
Acute coronary syndrome | 51 (4.8) | 1 (2.6) | .507 | -11.67% |
Chronic liver failure | 45 (4.2) | 1 (2.6) | .609 | -8.84% |
Hematologic malignancy | 12 (1.1) | 0 | .359 | -14.91% |
Solid tumor | 124 (11.6) | 4 (10.5) | .837 | -3.51% |
Risk factors, number (%) | ||||
Urinary catheter | 1,057 (99.1) | 37 (97.4) | .387 | -12.99% |
Central venous catheter | 1,044 (97.8) | 38 (100.0) | .193 | 21.21% |
Mechanical ventilation | 967 (90.5) | 37 (97.4) | .097 | 29.24% |
Broad-spectrum antibiotics | 941 (88.3) | 36 (97.3) | .046 | 35.36% |
Empiric/preemptive antifungal treatment. | 180 (16.8) | 2 (5.3) | .032 | -37.31% |
Arterial catheter | 846 (79.5) | 37 (97.4) | .001 | 58.33% |
Enteral nutrition | 825 (77.2) | 26 (68.4) | .225 | -19.87% |
Total parenteral nutrition | 428 (40.4) | 27 (71.1) | < .001 | 64.99% |
Corticosteroids | 300 (28.5) | 12 (31.6) | .679 | 6.76% |
Renal replacement therapy | 126 (12.0) | 15 (39.5) | < .001 | 66.25% |