Antipsychotic use and diagnosis of delirium in the intensive care unit

Table 4 Clinical outcomes of patients

Clinical outcomes	Delirium 10,034 (6.1%)	No delirium 154,962 (93.9%)	P-value	Antipsychotic exposure 17,764 (10.6%)	No antipsychotic exposure 140,865 (85.4%)^a	P-value
ICU LOS, median days (IQR)	5 (3 to 10)	3 (2 to 5)	< 0.001	8 (4 to 15)	3 (2 to 4)	< 0.001
Hospital LOS
Observed, median days (IQR)	11 (6 to 19)	6 (3 to 11)	< 0.001	14 (7 to 24)	5 (3 to 10)	< 0.001
Expected, median days (IQR)	10 (7 to 15)	7 (5 to 10)	< 0.001	13 (9 to 21)	7 (5 to 10)	< 0.001
Mortality
Observed, %	8.3	8.6	0.419	12.2	8.1	< 0.001
Expected, %	11.5	8.3	< 0.001	14.0	7.8	< 0.001

Results compare outcomes for patients with an admission to an intensive care unit with documentation of delirium versus none and with antipsychotic exposure versus none (n = 164,996). ^aDue to equivocal data for antipsychotic administration, 4% (n = 6,367) of patients were excluded from antipsychotic exposure versus no antipsychotic exposure comparisons. ICU, intensive care unit; LOS, length of stay

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