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Table 4 Changes in ventilator setup

From: Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial

 

All patients

Optimized ventilation

Standard ventilation

P

At the beginning of NIV

    

   PEEP, cmH2O

5.1 ± 1.4

5.5 ± 1.7

4.7 ± .9

.003

   PS, cmH2O

13.6 ± 3.4

14.0 ± 3.7

13.2 ± 3.1

.152

   Insp trigger*, L/minute

3.2 ± 2.0

2.3 ± 1.8

4.0 ± 1.7

.002

   Expiratory trigger, %

40 ± 9

38 ± 9

42 ± 8

.086

   Speed of pressurization

1.8 ± .6

1.7 ± .6

2.0 ± .4

.024

After 30 minutes of NIV

    

   PEEP, cmH2O

5.4 ± 1.3

5.9 ± 1.4

4.9 ± .9

.011

   PS, cmH2O

14.3 ± 3.5

14.7 ± 3.7

14.0 ± 3.4

.604

   Insp trigger*, L/minute

2.9 ± 2.0

2.0 ± 1.7

3.8 ± 1.8

.001

   Expiratory trigger, %

40 ± 12

40 ± 14

40 ± 9

.600

   Speed of pressurization

1.6 ± .5

1.4 ± .5

1.7 ± .4

.011

After 2 hours of NIV

    

   PEEP, cmH2O

5.4 ± 1.2

5.9 ± 1.3

4.9 ± .9

.030

   PS, cmH2O

14.8 ± 3.9

14.9 ± 4.2

14.7 ± 3.7

.820

   Insp trigger*, L/minute

2.9 ± 2.0

1.9 ± 1.7

4.1 ± 1.7

0.001

   Expiratory trigger, %

37 ± 12

36 ± 14

38 ± 10

.337

   Speed of pressurization

1.4 ± .5

1.3 ± .5

1.6 ± .5

.064

After 6 hours of NIV

    

   PEEP, cmH2O

5.4 ± 1.4

5.8 ± 1.6

5.1 ± 1.0

.015

   PS, cmH2O

15.3 ± 4.0

15.5 ± 4.2

15.1 ± 4.0

.925

   Insp trigger*, L/minute

3.0 ± 2.0

2.0 ± 1.7

3.9 ± 1.8

.001

   Expiratory trigger, %

37 ± 11

36 ± 12

39 ± 10

.143

   Speed of pressurization

1.6 ± .5

1.5 ± .6

1.7 ± .5

.134

After 24 hours of NIV

    

   PEEP, cmH2O

5.4 ± 1.5

6.0 ± 1.8

4.9 ± .9

.002

   PS, cmH2O

14.8 ± 3.9

15.4 ± 4.2

14.3 ± 3.6

.426

   Insp trigger*, L/minute

3.1 ± 1.9

2.4 ± 1.8

4.0 ± 1.8

.009

   Expiratory trigger, %

37 ± 11

37 ± 12

37 ± 10

.708

   Speed of pressurization

1.7 ± .6

1.5 ± .5

1.9 ± .6

.089

  1. Data reported as mean ± standard deviation. Insp trigger, inspiratory trigger; PEEP, external positive end expiratory pressure; PS, pressure support (over PEEP). Speed of pressurization: data are reported in a qualitative scale ranging from 0 (faster pressurization) to 5 (slower pressurization). *Data available in 50 patients. Significant differences in bold.