From: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study
Baseline | 12 hours | 18 hours | 22 hours | |
---|---|---|---|---|
Creatinine (μmol/L) | ||||
AKI-INF | 95 (84-114) | 92 (88-148) | 105 (85-168) | 150 (134-180)ab |
AKI-PERIT | 98 (93-105) | 107 (97-128) | 129 (112-158)c | 131 (129-166)ac |
NONAKI-INF | 106 (97-120) | 100 (95-107) | 102 (95-110) | 109 (95-117) |
NONAKI-PERIT | 91 (84-91) | 81 (78-96) | 81 (77-91) | 89 (84-94) |
Renal vascular resistance (mm Hg/L/min) | ||||
AKI-INF | 359 (235-635) | 373 (288-700) | 576 (273-1,161) | 2,433 (1061-2,727)a |
AKI-PERIT | 376 (302-459) | 448 (280-637) | 516 (236-821) | 464 (404-1,425) |
NONAKI-INF | 471 (352-539) | 388 (341-503) | 415 (315-556) | 355 (325-779) |
NONAKI-PERIT | 500 (431-541) | 386 (320-407) | 302 (273-340)a | 383 (339-438) |
Renal-to-systemic vascular resistance ratio | ||||
AKI-INF | 14 (11-17) | 21 (13-32) | 28 (17-58) | 94 (49-170)a |
AKI-PERIT | 12 (10-14) | 25 (14-59) | 39 (20-59)a | 38 (20-143)a |
NONAKI-INF | 15 (14-19) | 18 (16-35) | 23 (16-40) | 30 (19-63)a |
NONAKI-PERIT | 16 (14-16) | 18 (13-21) | 16 (15-17) | 24 (18-48) |
Renal flow (ml/min/kg) | ||||
AKI-INF | 6 (6-11) | 6 (3-8) | 4 (2-7) | 1 (1-2)a |
AKI-PERIT | 7 (5-8) | 4 (3-5) | 4 (2-6) | 3 (1-4)a |
NONAKI-INF | 5 (4-7) | 4 (3-5) | 5 (3-5) | 4 (2-5) |
NONAKI-PERIT | 6 (5-6) | 7 (6-8) | 7 (7-9)a | 6 (4-6) |
Renal cortical microcirculation (laser Doppler flowmetry) (% of baseline value) | ||||
AKI-INF | 100 (100-100) | 70 (57-105) | 67 (55-97) | 35 (25-51)a |
AKI-PERIT | 100 (100-100) | 59 (36-72)a | 61 (41-85) | 57 (32-75)a |
NONAKI-INF | 100 (100-100) | 63 (53-111) | 64 (52-101) | 65 (47-92) |
NONAKI-PERIT | 100 (100-100) | 88 (70-99) | 75 (62-111) | 59 (49-85)a |
Diuresis (ml/kg/h) | ||||
AKI-INF | 1.7 (1-2.7) | 2.7 (2.2-8) | 4.8 (1.8-8.1) | 1.1 (0.1-3.8) |
AKI-PERIT | 1.5 (1.3-1.9) | 1.8 (1.5-2.3) | 1.6 (0.9-2.1) | 0.6 (0.2-0.9)ac |
NONAKI-INF | 2.2 (1.3-2.5) | 4.5 (3.8-5.5)a | 4.2 (1.7-5.4) | 1.3 (1-2.3) |
NONAKI-PERIT | 1.6 (1.3-2.4) | 2.3 (2-4.8) | 3.9 (2.9-6.5) | 1.7 (1.5-3.6) |
TNF-α (pg/g of protein) | ||||
AKI-INF | 2 (2-3) | 8 (6-19)a | 14 (12-31)a | 25 (20-42)a |
AKI-PERIT | 1 (1-3) | 10 (5-16) | 18 (5-30)a | 18 (5-105)a |
NONAKI-INF | 2 (1-3) | 4 (4-5) | 18 (10-22)a | 7 (6-15)a |
NONAKI-PERIT | 1 (1-1) | 3 (2-7) | 9 (5-15) | 16 (6-30)a |
IL-6 (pg/g of protein) | ||||
AKI-INF | 2 (1-5) | 62 (5-104) | 70 (33-130)a | 155 (67-383)a |
AKI-PERIT | 3 (1-8) | 118 (28-327) | 246 (70-1,161)a | 284 (68-3,981)a |
NONAKI-INF | 2 (2-5) | 6 (5-10) | 32 (27-51)a | 61 (18-84)a |
NONAKI-PERIT | 3 (1-4) | 12 (6-29) | 19 (5-221) | 33 (7-1,186)a |
NOx (μmol/g of protein) | ||||
AKI-INF | 0.8 (0.6-1) | 0.7 (0.6-0.7) | 0.9 (0.7-1.4) | 1.3 (0.9-1.5) |
AKI-PERIT | 0.8 (0.6-1.1) | 1.6 (1.2-3)ad | 1.6 (1.3-3.5)a | 1.1 (1-2.1) |
NONAKI-INF | 0.9 (0.6-1.1) | 0.5 (0.4-0.8) | 0.7 (0.5-1) | 0.8 (0.7-1.4) |
NONAKI-PERIT | 0.8 (0.7-0.9) | 1.2 (1-1.5) | 1.3 (0.8-1.7) | 1.5 (1.3-1.7)a |
TBARS (pg/g of protein) | ||||
AKI-INF | 14 (11-15) | 26 (14-41) | 31 (24-36)a | 36 (27-61)a |
AKI-PERIT | 21 (18-25)d | 68 (49-93)ad | 90 (58-129)ad | 75 (55-132)a |
NONAKI-INF | 14 (13-14) | 22 (19-23) | 32 (22-39)a | 30 (27-40)a |
NONAKI-PERIT | 18 (16-21) | 35 (32-48) | 77 (44-91)a | 62 (39-106)a |