Table 1 Characterization of sepsis models
From: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study
Baseline | 12 hours | 18 hours | 22 hours | |
|---|---|---|---|---|
Mean arterial pressure (mm Hg) | ||||
Control | 95 [87-109] | 86.5 [83-94] | 80 [73-90] | 84 [68-87] |
Infusion | 112 [103-122] | 88 [79-100]a | 82 [77-90]a | 79 [74-88]a |
Peritonitis | 97 [92-104] | 89 [73-99] | 81 [69-97]a | 76 [68-91]a |
Cardiac output (ml/kg) | ||||
Control | 98 (90-105) | 97 (85-100) | 80 (76-87) | 85 (77-98) |
Infusion | 90 (80-101) | 98 (80-128) | 98 (81-130) | 106 (83-145) |
Peritonitis | 81 (67-97) | 118 (97-148)a | 129 (110-157)ab | 152 (101-181)ab |
Systemic vascular resistance (dyne.s.cm -5 ) | ||||
Control | 2,453 (1,838-2,700) | 2,075 (1,935-2,299) | 1,961 (1,872-2,169) | 1,912 (1,648-2,262) |
Infusion | 2,457 (1,956-2,643) | 1,562 (1,384-1,788)a | 1,382 (1,116-1,698)ab | 1,179 (873-1,692)a |
Peritonitis | 2,737 (2,003-2,858) | 1,635 (1,102-1,978)b | 1,165 (849-1,595)ab | 853 (651-1,393)ab |
ITBVI (ml/kg) | ||||
Control | 31 (28-33) | 24 (21-34) | 23 (21-30) | 26 (23-28) |
Infusion | 27 (22-29) | 25 (22-27) | 24 (20-28) | 23 (21-24) |
Peritonitis | 23 (22-26) | 26 (22-31) | 27 (23-29) | 23 (19-34) |
DO 2 systemic (ml/min/kg) | ||||
Control | 11.9 (9.9-12.2) | 11.1 (9.3-12.1) | 9.2 (8.7-10.7) | 9.6 (8.8-10.3) |
Infusion | 11.5 (9.6-12.5) | 12 (9.2-15.5)c | 12.2 (10.1-15) | 11.9 (9.6-16.1)c |
Peritonitis | 11.4 (9-13.6) | 16 (14.5-23.2)b | 16.4 (15-21.9)ab | 22.1 (13.4-24.5)ab |
VO 2 systemic (ml/min/kg) | ||||
Control | 5.6 (4.6-5.9) | 5.5 (5.2-5.7) | 4.8 (4.7-5.8) | 3.3 (2.7-4.3)a |
Infusion | 4.5 (4.2-5.0) | 5.2 (5-7.4)a | 5.1 (4.7-6.9) | 4.6 (3.5-6.2) |
Peritonitis | 4.8 (4.3-5.6) | 5.9 (5.2-6.8) | 5.6 (4.8-6.3) | 7.2 (4.2-9.5) |
PaO 2 /FiO 2 (mm Hg) | ||||
Control | 489 (445-514) | 399 (374-456) | 412 (320-434) | 432 (272-449) |
Infusion | 463 (348-502) | 251 (164-352)ab | 292 (191-350) | 135 (66-205)ab |
Peritonitis | 456 (336-497) | 340 (309-381) | 173 (115-305)b | 137 (80-286)a |
TNF-α (pg/g of protein) | ||||
Control | 1 (1-5) | 3 (1-5) | 2 (1-6) | 2 (1-5) |
Infusion | 2 (2-3) | 5 (4-7)a | 16 (10-23)ab | 13 (7-25)ab |
Peritonitis | 1 (1-2) | 7 (5-10)ab | 13 (5-24)ab | 18 (5-33)ab |
IL-6 (pg/g of protein) | ||||
Control | 2 (1-2) | 1 (1-1)a | 1 (0-1)a | 1 (1-2) |
Infusion | 2 (1-5) | 7 (5-18)b | 34 (27-101)ab | 72 (23-175)ab |
Peritonitis | 3 (1-5) | 29 (11-193)ab | 126 (16-484)ab | 203 (20-1,296)ab |
TBARS (nmol/g of protein) | ||||
Control | 16 (14-18) | 19 (16-28)a | 24 (18-34)a | 23 (16-26)a |
Infusion | 14 (13-15)c | 22 (19-27)c | 32 (23-39)ac | 30 (27-46)ac |
Peritonitis | 18 (17-24) | 52 (37-76)ab | 84 (51-114)ab | 70 (46-107)ab |