Table 6 Univariate logistic regression analysis of mortality related to multiple prognostic factors; (N = 323)

Age ¹ , years

57.4 ± 15.5

58.4 ± 14.2

1.00 (0.98 to 1.02)

0.607

Gender ² , males (%)

192 (70.8)

32 (61.5)

1.24 (0.64 to 2.41)

0.525

Pre-existing disease ²

   Fever, n (%)

85 (31.4)

18 (34.6)

1.16 (0.62 to 2.17)

0.645

   Tachycardia

126 (46.5)

26 (50.0)

1.05 (0.58 to 1.90)

0.872

   Hypotension

30 (11.1)

12 (23.1)

7.07 (3.48 to 14.37)

<.001*

   Diabetes mellitus

167 (61.6)

28 (53.8)

1.06 (0.58 to 1.95)

0.851

   Heart disease

37 (13.7)

6 (11.5)

3.52 (1.72 to 7.20)

0.001*

   Peripheral vascular disease

23 (8.5)

4 (7.7)

0.39 (0.09 to 1.71)

0.214

   Renal disease

49 (18.1)

11 (21.2)

1.59 (0.79 to 3.21)

0.196

   Liver disease

74 (27.3)

17 (32.7)

2.37 (1.28 to 4.37)

0.006*

   Intravenous drug use

14 (5.2)

1 (1.9)

0.36 (0.05 to 2.80)

0.329

Clinical features ²

   Affected site (limbs)

228 (84.1)

48 (92.3)

1.11 (0.47 to 2.64)

0.808

   Bullae formation

109 (40.2)

23 (44.2)

1.18 (0.65 to 2.15)

0.590

   Operation within 24 hours

187 (69.0)

35 (67.3)

0.68 (0.35 to 1.26)

0.224

   Amputation

70 (25.8)

13 (25.0)

1.86 (0.99 to 3.50)

0.053

   Debridement > = 3 times

157 (57.9)

11 (21.2)

0.19 (0.10 to 0.39)

<.001*

Multiple Etiologic agent in Wound culture ² , n (%)

129 (47.6)

24 (46.2)

0.94 (0.52 to 1.71)

0.848

Gram positive organism in wound culture ²

   Streptococcus group A

32 (11.8)

5 (9.6)

0.79 (0.29 to 2.14)

0.650

   Streptococcus group B

4 (1.5)

2 (3.8)

2.67 (0.48 to 14.97)

0.264

Methicillin-susceptible

S. aureus

39 (14.4)

3 (5.8)

0.36 (0.11 to 1.23)

0.103

   Methicillin-resistant S. aureus

47 (17.3)

7 (13.5)

0.74 (0.31 to 1.74)

0.493

Gram negative organism in wound culture ²

   Acinetobacter baumannii

20 (7.4)

3 (5.8)

0.77 (0.22 to 2.69)

0.680

   Aeromonas spp.

18 (6.6)

4 (7.7)

1.17 (0.38 to 3.61)

0.783

   E.coli

29 (10.7)

8 (15.4)

1.52 (0.65 to 3.54)

0.334

   K.pneumoniae

36 (13.3)

5 (9.6)

0.69 (0.26 to 1.86)

0.469

   Proteus mirrabilis

23 (8.5)

0 (0)

-

-

   Pseudomonas spp.

16 (5.9)

3 (5.8)

0.98 (0.27 to 3.48)

0.970

   Vibrio spp.

11 (4.1)

11 (21.2)

6.37 (2.58 to 15.57)

<.001*

Fungus in wound culture ²

6 (2.2)

1 (1.9)

6.34 (2.58 to 15.57)

<.001*

Multiple Etiologic agent in blood culture ² , n (%)

3 (1.1)

1 (1.9)

1.75 (0.18 to 17.17)

0.630

Gram positive organism in blood culture ²

   Streptococcus group A

2 (0.7)

3 (5.8)

8.24 (1.34 to 50.56)

0.023*

   Streptococcus group B

1 (0.4)

1 (1.9)

5.29 (0.33 to 86.01)

0.241

Methicillin-susceptible

S. aureus

10 (3.7)

0 (0)

-

-

   Methicillin-resistant S. aureus

5 (1.8)

2 (3.8)

2.13 (0.40 to 11.27)

0.375

Gram negative organism in blood culture ²

   Acinetobacter baumannii

0 (0)

2 (3.8)

-

-

   Aeromonas spp.

3 (1.1)

3 (5.8)

5.47 (1.07 to 27.89)

0.041*

   E.coli

3 (1.1)

2 (3.8)

3.57 (0.58 to 21.93)

0.169

   Proteus mirrabilis

0 (0)

1 (1.9)

-

-

   Vibrio spp.

11 (4.1)

9 (17.3)

4.95 (1.94 to 12.64)

0.001*