Figure 1

Schematic diagram of the mechanisms involved in viral vector-mediated gene therapy. The adenoviral vector encoding a new gene of interest binds to a cell membrane, becoming internalized within a vesicle, is subsequently released from the vesicle and is transported towards the nucleus, where it releases its genetic material, which is subsequently transcribed and translated to produce the therapeutic protein. This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, and is in the public domain.