The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets

Table 2 Effects (means ± SD) of dopamine infusions in six anesthetized hypoxic piglets

	Normoxia	1 h hypoxia	2i	2f	10i	10f	32i	32f
SAP/PAP ratio	3.4 ± 0.65^§	2.0 ± 0.27	1.7 ± 0.32	1.6 ± 0.21	1.7 ± 0.33	1.8 ± 0.60	1.4 ± 0.12^*†	1.4 ± 0.20^*†
MVRI (mmHg ml^-1 kg^-1 min^-1)	1.86 ± 0.49	2.00 ± 0.55	2.07 ± 0.82	1.98 ± 0.84	1.99 ± 0.86	2.07 ± 0.86	1.45 ± .74^*†	1.21 ± .46^*†
Systemic DO₂ (ml kg^-1 min^-1)	33 ± 5^§	19 ± 5	23 ± 8	24 ± 8	21 ± 6	21 ± 6	20 ± 4	19 ± 4
Systemic EO₂ (%)	28 ± 11.7^§	43 ± 12.6	42 ± 12.7	42 ± 13.8	39 ± 7.5	39 ± 10.8	42 ± 11.4	40 ± 13.1
Splanchnic EO₂ (%)	20 ± 6.7^§	39 ± 9.3	37 ± 13.2	35 ± 14.6	33 ± 11.3	30 ± 9.1	24 ± 11.4	26 ± 13.9
Systemic VO₂ (ml kg^-1 min^-1)	7.02 ± 3.36	6.16 ± 2.14	6.78 ± 2.80	7.13 ± 2.57	6.54 ± 3.40	6.04 ± 2.00	6.27 ± 2.14	5.80 ± 2.33
Splanchnic VO₂ (ml kg^-1 min^-1)	1.19 ± 0.42	1.07 ± 0.15	1.10 ± 0.32	1.11 ± 0.22	1.07 ± 0.36	0.97 ± 0.36	0.84 ± 0.49	1.02 ± 0.44
Hepatic DO₂ (ml kg^-1 min^-1)	5.86 ± 0.92^§	2.29 ± 0.87	2.56 ± 1.07	2.88 ± 1.26	2.73 ± 0.85	2.82 ± 0.90	3.32 ± 1.26	3.61 ± 1.25^*
Hepatic DO₂ ratio (%)	17 ± 14.2	20 ± 13.1	18 ± 13.2	19 ± 14.2	18 ± 12.1	16 ± 11.1	13 ± 11.3	10 ± 8.6
(HAFI + PVFI)/CI (%)	28 ± 4^§	23 ± 3	23 ± 5	23 ± 4	26 ± 12	27 ± 11	27 ± 5	32 ± 6!
Arterial lactate (mM)		9.2 ± 6.6		9.4 ± 4.7		12.0 ± 7.1		10.2 ± 4.9

i, initial (3 min average at 30 min of infusion); f, final (3 min average at 60 min of infusion). ^*P < 0.05 compared with variables at 1 h of hypoxia (one-way repeated measures ANOVA); ^†P < 0.05 compared with variables during all doses of epinephrine infusion (two-way ANOVA); ^§P < 0.05 for difference between normoxia baseline and 1 h of hypoxia. EO₂, oxygen extraction; DO₂, oxygen delivery; MVRI, mesenteric vascular resistance index; hepatic DO₂ ratio, the proportion of hepatic DO₂ accounted for by hepatic arterial oxygen delivery; (HAFI + PVFI)/CI, total hepatic blood flow as a proportion of the cardiac index.

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