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Table 1 Effects (means ± SD) of prolonged hypoxia in five anesthetized control piglets

From: The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets

 

Normoxia

1 h hypoxia

2 h hypoxia

3 h hypoxia

4 h hypoxia

Cardiac index (ml kg-1 min-1)

136 ± 25

151 ± 49*

154 ± 50*

151 ± 35*

142 ± 43

Arterial saturation (%)

99 ± 0.5

61 ± 6*

63 ± 3*

59 ± 4*

60 ± 4*

Systemic DO2 (ml kg-1 min-1)

20 ± 3.4

14 ± 2.2*

13 ± 1.6*

14 ± 3.7*

13 ± 3.7*

SAP (mmHg)

83 ± 20

79 ± 15

79 ± 15

75 ± 15

73 ± 16*

PAP (mmHg)

25 ± 2

37 ± 7*

37 ± 7*

38 ± 7*

40 ± 6*

PVRI (mmHg ml-1 kg-1 min-1)

0.19 ± 0.04

0.27 ± 0.11*

0.25 ± 0.09*

0.26 ± 0.07*

0.30 ± 0.06*

SAP/PAP ratio

3.3 ± 0.6

2.2 ± 0.5*

2.2 ± 0.5*

2.0 ± 0.4*

1.8 ± 0.4*

Systemic EO2 (%)

27 ± 5.5

46 ± 14*

44 ± 13*

43 ± 13*

44 ± 11*

  1. EO2, oxygen extraction; DO2, oxygen delivery. *P < 0.05 compared with normoxic baseline.