From: Critical care medicine in the 21st century: from CPR to PCR
Disease/syndrome | Physiological event | Clinical presentation | Molecular process | Potential new therapy |
---|---|---|---|---|
Bacterial pneumonia | Alveolar exudate | Pulmonary dysfunction | Change in cell surface | Inhaled anti-inflammatory |
receptor affinity for | cytokines | |||
Inflammatory infiltrates | microorganisms | |||
Antibiotic therapy based on | ||||
Cell damage | Immune suppression | bacterial DNA susceptibility | ||
Shock | Tissue ischemia | Organ hypoperfusion | Upregulation of ROS | Endothelial growth factors |
Endothelial damage | Reduced NOS synthesis | ROS scavengers | ||
Ventilator-induced | Alveolar disruption | Respiratory failure | Decreased synthesis and | Lung protective ventilatory |
lung injury | denaturation of surfactant | strategies | ||
Alveolar/interstitial edema | ||||
Upregulation of inflammatory | Inhaled anti-inflammatory | |||
Capillary stress | cytokines | cytokines | ||
SIRS | Immune suppression | Multiple organ dysfunction | Upregulation of acute phase | IL-10 gene expression vector |
proteins and cytokines | ||||
Sustained low grade | Blocking EBP cellular | |||
inflammation | receptors |