Table 1 On-going studies
From: The acute management of trauma hemorrhage: a systematic review of randomized controlled trials
On-going study | Clinical group of trauma patients | Intervention details | Comparator details | Primary endpoint | Target number to be recruited | Expected end date |
|---|---|---|---|---|---|---|
CRISTAL: Colloids versus crystalloids for resuscitation of critically ill patients | ITU patients, fluid resuscitation | Colloids | Crystalloids | 28 day mortality | 3,010 | March 2011 |
High versus low MAP for trauma patients undergoing surgery | Adults, SBP < 90 mmHg, requiring laparotomy or thoracotomy, | Target minimum mean arterial BP 50 mmHg | Target minimum mean arterial BP 65 mmHg | 30 day survival | 271 | July 2011 |
FIRST: Colloids versus crystalloids for resuscitation of trauma patients | Adults, requiring ≥3 litres of fluid | HES 130/0.4 in saline (Voluven) | 0.9% saline | Fluid volumes over first 24 hours | 140 | December 2009 |
Formula-driven vs. laboratory-guided transfusion in bleeding trauma patients: a feasibility study | Adults, requiring four units of RBC in two hours and ongoing blood loss | FFP:RBC:platelets ratio of 1:1:1 - formula | Standard of care | Protocol compliance at 12 hours | 70 | October 2011 |