Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis

Table 3 Cox regression analyses of factors associated with in-hospital mortality of the 86 included patients

	Univariable analysis		Multivariable analysis
Factor	HR	P-v alue	HR	95% CI	P-v alue
CMV reactivation	0.410	0.029	0.369	0.136 to 1.005	0.051
SAPS II at inclusion	1.062	<0.001	1.047	1.012 to 1.082	0.008
Septic Shock present	2.193	0.081	1.470	0.555 to 3.896	0.438
ICU stay before enrolment	1.010	0.298	1.022	0.999 to 1.046	0.058
HSV detection in respiratory secretions	1.539	0.268	1.546	0.687 to 3.480	0.292
Optimized model
CMV reactivation			0.496	0.215 to 1.145	0.101
SAPS II at inclusion			1.056	1.024 to 1.089	<0.001
Landmark analysis for Day 0, Day 7 and Day 14
Day 0 (86 patients, 12 of them with CMV reactivation)
CMV reactivation	0.983	0.974	1.005	0.347 to 2.911	0.993
SAPS II at inclusion	1.062	<0.001	1.062	1.030 to 1.096	<0.001
Day 7 (75 patients, 18 of them with CMV reactivation)
CMV reactivation	0.559	0.259	0.486	0.173 to 1.370	0.172
SAPS II at inclusion	1.063	0.001	1.064	1.027 to 1.102	<0.001
Day 14 (62 patients, 20 of them with CMV reactivation)
CMV reactivation	0.707	0.492	0.561	0.204 to 1.544	0.263
SAPS II at inclusion	1.065	0.003	1.067	1.026 to 1.111	0.001

CMV, cytomegalovirus; HR, hazard ratio; HSV, herpes simplex virus; SAPS, Sequential Organ Failure Assessment score.

ISSN: 1364-8535