Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

Table 2 Comparison of patients with different measured creatinine clearance (CL_CR)

	Cl_CR < 120 (n= 178)	Cl_CR > 120 (n= 106)	P*	Cl_CR < 60 (n= 63)	Cl_CR > 60 (n= 221)	P ^#	P§
Age (yr)	56 ± 18	40 ± 16	< 0.0001	63 ± 15	46 ± 18	< 0.0001	< 0.0001
Weight (Kg)	74 ± 17	74 ± 14	NS	73 ± 19	74 ± 15	NS	NS
Sex (F/M)	64/114	24/82	0.03	35/28	161/60	NS	0.0032
Ideal body weight (Kg)	69 ± 12	72 ± 10	0.01	65 ± 11	71 ± 11	0.0002	< 0.0001
SAPS 2	50 ± 15	43 ± 14	0.0002	54 ± 14	45 ± 15	< 0.0001	< 0.0001
Serum creatinine (μmol L^-1)	76 ± 24	67 ± 19	0.0001	85 ± 25	69 ± 20	< 0.0001	< 0.0001
Diuresis/24H	2,400 ± 100	2,800 ± 1200	< 0.0001	584 ± 224	1,418 ± 694	0.0019	< 0.0001
Measured creatinine clearance (mL min^-1 .1.73 m^-2)	74 ± 30	166 ± 50	< 0.0001	43 ± 11	127 ± 50	< 0.0001	< 0.0001
Simplified MDRD (mL minute^-1 1.73 m^-2)	96 ± 39	119 ± 45	< 0.0001	81 ± 34	112 ± 43	< 0.0001	< 0.0001
Cockcroft-Gault (mL minute^-1 1.73 m^-2)	98 ± 39	130 ± 34	0.0005	80 ± 39	118 ± 36	< 0.0001	< 0.0001
Robert (mL minute^-1 1.73 m^-2)	72 ± 23	94 ± 23	< 0.0001	59 ± 2	85 ± 2	< 0.0001	< 0.0001
PT ^b/NPT ^a	65/113	79/27	< 0.0001	15/48	129/92	< 0.0001	< 0.0001

All data are expressed as ratio or mean ± SD.
* The P-values correspond to comparison between subgroup with CL_CR greater than 120 mL minute^-1 1.73 m^-2 versus subgroup with CL_CR lower than 120 mL minute^-1 1.73 m^-2.
^# The P-values correspond to comparaison between subgroup with CL_CR greater than 60 mL minute^-1 1.73 m^-2 versus subgroup with CL_CR lower than 60 mL minute^-1 1.73 m^-2.
§ The P-values correspond to comparison between less than 60 mL minute^-1 1.73 m^-2 more than 120 mL minute^-1 1.73 m^-2.
^a NPT = non-polytrauma patients.
^b PT = polytrauma patients.

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