%PDF-1.4
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Trauma,Traumatic brain injury,Intracranial hypertension,Brain oedema,Hyperosmolar therapy,Saline solution,Hypertonic,Sodium
Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
application/pdf
10.1186/s13054-017-1918-4
Critical Care
Critical Care, 2017, doi:10.1186/s13054-017-1918-4
Trauma
Traumatic brain injury
Intracranial hypertension
Brain oedema
Hyperosmolar therapy
Saline solution
Hypertonic
Sodium
Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury – a multicentre prospective cohort study and systematic review
Karim Asehnoune
Sigismond Lasocki
Philippe Seguin
Thomas Geeraerts
Pierre François Perrigault
Claire Dahyot-Fizelier
Catherine Paugam Burtz
Fabrice Cook
Dominique Demeure dit latte
Raphael Cinotti
Pierre Joachim Mahe
Camille Fortuit
Romain Pirracchio
Fanny Feuillet
Véronique Sébille
Antoine Roquilly
2018-02-13T00:26:47+01:00
2018-01-27T19:45:16+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2018-02-13T00:26:47+01:00
uuid:ba8a7523-c827-41b0-8b7b-bb3f66eeda78
uuid:18f8211d-b122-4617-9e1e-5bf892b5cfe9
default
1
converted
uuid:fc8bd545-a104-4971-b01a-ae8295ab4b40
converted to PDF/A-2b
pdfToolbox
2018-01-27T19:52:38+08:00
2
B
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
editorInfo
Bag EditorInformation
external
Editor information: contains the name of each editor and his/her ORCID identifier.
seriesEditorInfo
Bag SeriesEditorInformation
external
Series editor information: contains the name of each series editor and his/her ORCID identifier.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
EditorInformation
http://springernature.com/ns/xmpExtensions/2.0/editorInfo/
editor
Specifies the types of editor information: name and ORCID of an editor.
name
Text
Gives the name of an editor.
orcid
URI
Gives the ORCID of an editor.
SeriesEditorInformation
http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/
seriesEditor
Specifies the types of series editor information: name and ORCID of a series editor.
name
Text
Gives the name of a series editor.
orcid
URI
Gives the ORCID of a series editor.
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
internal
A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.
DerivedFrom
ResourceRef
Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.
http://ns.adobe.com/xap/1.0/sType/Part#
stPart
Part
http://ns.adobe.com/xap/1.0/t/pg/
xmpTPg
XMP Paged-Text
internal
A structure containing the characteristics of a font used in a document
Fonts
Bag Font
internal
XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).
PlateNames
Seq Text
A structure containing the characteristics of a font used in a document.
http://ns.adobe.com/xap/1.0/sType/Font#
stFnt
Font
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
endstream
endobj
3 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/ColorSpace<>/Font<>>>/MediaBox[0 0 595.276 790.866]/Thumb 16 0 R/Annots[17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R]/Rotate 0>>
endobj
4 0 obj
<>
endobj
5 0 obj
<>stream
x\rFv?OT*`ՐFwsيמq<쏑+ h F/ϑȣ[s őDNj$>o>xզ{e,^ջo?W]
gW[ᄏy^ݴᄍ1^;.U(%NIn$qEݧbmln`58AE9_ǁ29c)#Cʗ8
-Z[v;y[<$A]A//A_QǮnV/oEL+AG5OOr!v64xlT+Wb2%5K]/DKs
|$O}X"OaՖ܌]+Wq %Zlp#
V~bUvx%>_2.386 69e><.BtpAJa'zU*pו
y\]n'*2RCe^_BIц{`S=xI(퓾?Bp8oEg#Eí*ȓpU}^gTemER&R7M{9K`A[]flDT,Ե^̛OlOE.nfF/GWq(G"@H#r͎sQ^&Ya$9y.VkL)Hfq w ddra|?HA.t]䗪|L&9渳l~e]&hw|gҷdEM
-b.9aǪdoMy1J/Xo?9Z17"`ž)p -״.5d@s-Z-Z2&47'PX
ˋޮאuWགྷȾD"y-wej8kS+WՒ[f`Eaă7Egɶ( Khd 1(p>w?SoZY
D~GS\Mj`s++Fiʶ/šn]s3u
>\S.qv%ۖM[m"*qne@*8bl]bL=\
ˌ4>ז¾.N/5mdD9',_{N^X6tXzl]2/t{"VTkRh^;UM)̨SkƋ?It|q˕8HI:"qbr I(F1cZeH]G80\NN/6QNyC^nhg02E\iȥ"PWLȱ,,Cvwq;J`2o#1:c܈_2Pxe0;&)9D~wyBHS>v7BQ"&KdJT^9%[oUh Q
.G<{2]I.qLB}sUMLmnsTʗuHBv˛>pZDs?YGt"G|4|)\B7,L/ހA\&Px\Ua\:xαىdƘ!rnW[ZKʀ5~߈"2>Ƈ@nBe"D3$R3oqCBU3 .}R"XI^+\{ݮ+
hOu:c5pF8sxprZ b6\[5ep4 N?4ÐeOJICeWEoxHЯKIUl=Y*%a-듶xXŏ"NADOuɅ
Oj^4]2P,@BטIx(bwx5\np NIhMvSwOX=;.{*F\F.>uIfQ`B1J*/'wdrM9$C9EJVg($zD
60NP$rËܘ vi, ;ITS]a3"is$gq
φɷԾVc&|4`k/*Fdn\*6KI&Ihl>)LaGG1.fҙ'\mq*|2FŁ覑GOP2FRl8M\tšXw?UWpFJL>P@}K{?@(55*Y8H?W}ZTp6:Nڄ#Y0dF+.ojG{X'9S!&oCXX=tԂԞ?
յbj2e((hЏłyQ"XaVD\??DkZi?uG¢c s;udϖ|x\lcX+e01W#nHdk!ugW*^C|T⹘z!l0!{7nz}P_j= c
7e ZQ}n0.DRKP C3uNAk=<:pynd˙r۪b%ZM;&A*R7*C]_To~C>p,Pxz_W\WD!hlD˝
$GW_Q/.GVby_T<`_Ɇd9f
ivbiw4A]wăS@./Ƴb EJ[Gb(k4 l9Jz/օihUvbHIT[̈yAx0en嶀wM1>y.K"V"hs6vMnBu,H)4yn*+,QT}A,3SCcU
pXvPouaMVjl6*ikQ`p؋M}>'l(3bt?)\ѐv+>9EwnGq|;:.ύA5є;x(Ff;'
9[2Υ4
"> W$QS_9EU7
2>-m;.yL2ɨ7}Ps>2,,.S. ^4Ztq,c!qMx$fg_HQG:l9cQ!jn\s{
Vy(<:#o;KFwχ"`| v`!{-őGTI[)$=
p|zAOj .OkdHVjZfWV
98'2xDh^0yx<`Oi s@M'Ȝ1`ͯGIF8\;֦-T
oBd-EY !T8l}g8c_%nAM
b=%uW)<:oXˇ)PF ^(NaDTح$Q3j;kqqF#QD3"|mxZYD~|*5woUkPpYhh{<Fk-S 1A6H2Iߨ(zm>L\# JWr D#яǃ9]~fbW
]ơi&38_d8Zvh ޫ)PCs
s\d4lB{f4zp$v&W4F5m?p{&F`Pύ2{ ](r[
ث c4Mִ;lj)YiT3%_V.J譱![dH{Y xXG sme\ ҢfGj
4ghdCG!ǡjhDD=~El#&gdmjnyn!K2θuRho
34 J_}!\xy_^G.IxԬX)axD5{|1mAg稍|+CLJ$jt7u9:,ēbX+~nbr Vu #h,)w~lCY1zDU{B
:&r1v%.f髒0v}pO3 y۩?$.xm!f#p5[@;-7XgՃ4nOS.Ofl I~D2B[8~8;/$*K_Zx^K1i.V ΞO%ohOʐmm+5%+Ҿme"w9X|@!M݆R}zw^#'VZ=T1_amJKz݀]HǥF˥V05Hl}QڇěUJRPtaMӗ$-(s{s kŝV.XAleXAE/V gx]ȖTSK4Ҫq¥v
-kZ
Ъ9ʠ1E`Td;*Ņ>k2ۡiX@myVn
,+_4T#YNb_M_ȒtJ+OZ
oVs\B>4XeE's!3] [v%̏竽HA¡ZߴBb&td4fnȺwZmTĮi؍@\3t
5ʦ/:*kLKѤb
gq-
a6؝h wluIف$j|̖0KZkiZ?6ه[+=uڎ,=Y ˝^8E$igNSK/`\=牧H%bS'>\|yLn5y}SM
C$PmBȲ֧>ʌx(~u^-idد&2-
xP֨phn^!;g'NqCY<dbӄnJ&YGԄG<@4]_X(~h?ZˉDe2dCf&7AUz( EGV` ft-ԗǬiA4ַ5NGk`(ܳusVvo8nf)Usp&1)tn3/M!b~UmHlJ KIr뽞xpe,zƶ>"aWQ7S{'yb{|zx`I
0(# ~uN" oN)_lv1ظ8B%[` I*I0jGI
'<6ԒB:qs(J̯V'IpY#}U-$3
|[
~<̈mFTtL7$a^3"ޜ2.$EH%KՐk5S H1b~w9>,ۼ\GK^93-dC%A&F䀄)k+&Gp{@/*
iBr3A89a-b@|f(Yדx)pBgI;vح ^:@-O3mjxW8#b6]q0
t'iD&uvruK"#Θ've 쬑5ӲȻeݝ[OBfЙS)`3?VdZIIZW4PU*H6ѹ=K%gF܃﵇`J+BZWAי>Ն"k
0OQQU]اfts$3CR/Q%S/Zw_+4O
S<5qp3ݷ͌a$nQqa%ӑO2#]b $C]NH76/~ӒW!C:TpWs!Lqp,0#fD$
Tx#5}ʸFi+g
(&BMOݮ~3|AWKޫC=aXgO0:vFqmW`̻Ǽ(ym>
endobj
7 0 obj
[/ICCBased 43 0 R]
endobj
8 0 obj
<>/Subtype/Type1/FirstChar 1/FontDescriptor 45 0 R/Widths 46 0 R>>
endobj
10 0 obj
<>
endobj
9 0 obj
<>
endobj
12 0 obj
<>
endobj
11 0 obj
<>
endobj
13 0 obj
<>
endobj
15 0 obj
<>
endobj
14 0 obj
<>
endobj
16 0 obj
<>stream
xY[ }YrR'ia[+*݄E|-`P[,wޜʷ _
@]Z
8Bz=sr30z1qLd 6jG
0Y bbzZ,јf,fyq;O1?ah{ӊzx"ю*O':gjdkGi2XLxk7;`uO'zpZlƚΓH|Lmz12/fwvhx"twsbzaB gn$͙-ddz|d[Lz-U 9;2jVmil;Z9%9c?ne K$c(tLN-32;¶L;4tݵ+S#O;un >ȓ&u u=A&
endstream
endobj
17 0 obj
<